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DrugBank target: P28222

DrugBank target: P28222 (5HT1B_HUMAN)     

Example structure of target: 2g1x

( There are 3 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

5-hydroxytryptamine receptor 1B

S12, Serotonin 1D beta receptor, Serotonin receptor 1B, 5-HT-1B, 5-HT1B, 5-HT-1D-beta.

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2g1x
2g1x
2g1x
2g1x

Key:    PfamA domain  PfamB domain

Sequence length: 389 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 27 drugs for this target protein:

 

 
Generic name: DB01392 yohimbine
Formula: C21H26N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01186 pergolide
Formula: C19H26N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00714 apomorphine
Formula: C17H17No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00589 lisuride
Formula: C20H26N4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00315 zolmitriptan
Formula: C16H21N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00216 eletriptan
Formula: C22H26N2O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00268 ropinirole
Formula: C16H24N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00246 ziprasidone
Formula: C21H21Cln4Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00960 pindolol
Formula: C14H20N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00953 rizatriptan
Formula: C15H19N5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00918 almotriptan
Formula: C17H25N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00334 olanzapine
Formula: C17H20N4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00248 cabergoline
Formula: C26H37N5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00998 frovatriptan
Formula: C14H17N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00904 ondansetron
Formula: C18H19N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08807 bopindolol
Formula: C23H28N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01238 aripiprazole
Formula: C23H27Cl2N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00363 clozapine
Formula: C18H19Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00952 naratriptan
Formula: C17H25N3O2S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01200 bromocriptine
08Y
Formula: C32H40Brn5O5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00320 dihydroergotamine
2GM
Formula: C33H37N5O5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00696 ergotamine
ERM
Formula: C33H35N5O5
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00669 sumatriptan
Formula: C14H21N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00413 pramipexole
Formula: C10H17N3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06216 asenapine
Formula: C21H20Clno5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00571 propranolol
Formula: C16H21No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01224 quetiapine
Formula: C21H25N3O2S
Structure: There are no structures of this molecule in the PDB.

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