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Drug/nutraceutical targets classed as GO:0004871 - : signal transducer activity

Targets
Structure(s) of protein in PDB   No structures   Protein names shown in purple are human proteins.
Drugs
Target-drug structure(s) in PDB   Drug structure(s) in PDB   No structures.
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Alphabetical listing of protein targets and their drugs

  1.  
Adenosine A1 receptor P30542/AA1R_HUMAN
  Drugs:  theobromine, pentoxifylline, adenosine, defibrotide, caffeine, oxtriphylline, aminophylline, dyphylline, gabapentin, theophylline.
  2.  
Adenosine A2a receptor P29274/AA2AR_HUMAN
  Drugs:  theobromine, theophylline, mefloquine, regadenoson, oxtriphylline, caffeine, defibrotide, pentoxifylline, dyphylline, adenosine.
  3.  
Adenosine A2b receptor P29275/AA2BR_HUMAN
  Drugs:  enprofylline, theophylline, adenosine, defibrotide.
  4.  
Adenosine A3 receptor P33765/AA3R_HUMAN
  Drugs:  adenosine, aminophylline.
  5.  
Adrenocorticotropic hormone receptor Q01718/ACTHR_HUMAN
  Drugs:  cosyntropin, corticotropin.
  6.  
Alpha-1A adrenergic receptor P35348/ADA1A_HUMAN
  Drugs:  carvedilol, ergoloid mesylate, mephentermine, dipivefrin, ergonovine, terazosin, xylometazoline, isometheptene, asenapine, epinephrine, droxidopa, trimipramine, paliperidone, thioproperazine, flupenthixol, ergotamine, bromocriptine, alfuzosin, iloperidone, doxazosin, risperidone, olanzapine, dronedarone, trifluoperazine, acepromazine, nicardipine, tamsulosin, phentolamine, quetiapine, apraclonidine, ephedrine, norepinephrine, dihydroergotoxine, droperidol, thioridazine, chlorpromazine, amoxapine, promethazine, tolazoline, epinastine, sertindole, clozapine, phenoxybenzamine, maprotiline, bevantolol, escitalopram, metaraminol, pseudoephedrine, ziprasidone, amitriptyline, doxepin, levonordefrin, dapiprazole, oxymetazoline, citalopram, phenylephrine, phendimetrazine, methotrimeprazine, methoxamine, pergolide, trazodone, nortriptyline, dextroamphetamine, promazine, nefazodone, zuclopenthixol, desipramine, imipramine, phenylpropanolamine, aripiprazole, prazosin, midodrine, naphazoline, nicergoline, benzphetamine, labetalol, silodosin, propiomazine.
  7.  
Alpha-1B adrenergic receptor P35368/ADA1B_HUMAN
  Drugs:  ergotamine, prazosin, thioridazine, lisdexamfetamine, silodosin, doxazosin, acepromazine, ziprasidone, propiomazine, sertindole, promazine, dronedarone, chlorpromazine, droxidopa, norepinephrine, methotrimeprazine, risperidone, aripiprazole, olanzapine, methoxamine, thioproperazine, dextroamphetamine, xylometazoline, doxepin, pergolide, phenylephrine, modafinil, propericiazine, alfuzosin, dapiprazole, terazosin, phendimetrazine, bromocriptine, paliperidone, trimipramine, epinephrine, labetalol, nicardipine, tamsulosin, nefazodone, clozapine, midodrine, quetiapine.
  8.  
Alpha-1D adrenergic receptor P25100/ADA1D_HUMAN
  Drugs:  epinephrine, phenylephrine, pergolide, dapiprazole, dronedarone, quetiapine, tamsulosin, nortriptyline, droxidopa, promazine, norepinephrine, nicardipine, prazosin, bromocriptine, doxazosin, silodosin, imipramine, propiomazine, doxepin, ergotamine, terazosin, xylometazoline, sertindole, alfuzosin, amitriptyline, methotrimeprazine.
  9.  
Alpha-2A adrenergic receptor P08913/ADA2A_HUMAN
  Drugs:  phentolamine, asenapine, propericiazine, naphazoline, brimonidine, olanzapine, methyldopa, bromocriptine, dihydroergotoxine, droxidopa, mirtazapine, guanfacine, dronedarone, phenylpropanolamine, dexmedetomidine, tizanidine, oxymetazoline, ephedra, amoxapine, lofexidine, ropinirole, doxepin, aripiprazole, ergoloid mesylate, risperidone, epinephrine, xylometazoline, dihydroergotamine, mianserin, epinastine, amitriptyline, cabergoline, zuclopenthixol, pseudoephedrine, benzphetamine, paliperidone, fenoldopam, clozapine, methamphetamine, apraclonidine, phenoxybenzamine, pergolide, yohimbine, quetiapine, dipivefrin, tolazoline, guanabenz, clonidine, apomorphine, methotrimeprazine, trazodone, lisuride, lurasidone, pramipexole, ziprasidone, bethanidine, norepinephrine, ergotamine, nefazodone.
  10.  
Alpha-2B adrenergic receptor P18089/ADA2B_HUMAN
  Drugs:  tizanidine, yohimbine, pramipexole, clozapine, rotigotine, risperidone, quetiapine, cabergoline, etomidate, ephedra, apomorphine, fenoldopam, clonidine, paliperidone, doxepin, norepinephrine, dronedarone, lisuride, olanzapine, bromocriptine, ropinirole, ziprasidone, methamphetamine, brimonidine, methotrimeprazine, ergotamine, aripiprazole, phenoxybenzamine, droxidopa, pergolide, xylometazoline, trimipramine, bethanidine, epinephrine, asenapine.
  11.  
Alpha-2C adrenergic receptor P18825/ADA2C_HUMAN
  Drugs:  risperidone, methotrimeprazine, norepinephrine, ephedra, lurasidone, yohimbine, olanzapine, brimonidine, bromocriptine, pergolide, clonidine, tizanidine, methamphetamine, cabergoline, dronedarone, iloperidone, phenoxybenzamine, asenapine, clozapine, ropinirole, aripiprazole, doxepin, pramipexole, paliperidone, xylometazoline, apomorphine, lisuride, ziprasidone, fenoldopam, bethanidine, droxidopa, quetiapine.
  12.  
Aryl hydrocarbon receptor P35869/AHR_HUMAN
  Drugs:  ginseng, atorvastatin, flutamide, nimodipine, mexiletine, leflunomide.
  13.  
B2 bradykinin receptor P30411/BKRB2_HUMAN
  Drugs:  icatibant.
  14.  
Beta-1 adrenergic receptor P08588/ADRB1_HUMAN
  Drugs:  betaxolol, asenapine, bopindolol, pindolol, dobutamine, metoprolol, isoproterenol, sotalol, esmolol, bisoprolol, carvedilol, desipramine, norepinephrine, salbutamol, nadolol, oxprenolol, phenylpropanolamine, metipranolol, nebivolol, carteolol, isoetharine, practolol, dronedarone, timolol, droxidopa, pirbuterol, alprenolol, arbutamine, ephedra, bupranolol, bevantolol, propranolol, clenbuterol, atenolol, fenoterol, pseudoephedrine, acebutolol, levobunolol, epinephrine, amiodarone, labetalol.
  15.  
Beta-2 adrenergic receptor P07550/ADRB2_HUMAN
  Drugs:  acebutolol, ritodrine, arformoterol, isoproterenol, levobunolol, bambuterol, epinephrine, carteolol, metoprolol, orciprenaline, procaterol, propranolol, nebivolol, fenoterol, oxprenolol, timolol, betaxolol, alprenolol, desipramine, arbutamine, labetalol, clenbuterol, bisoprolol, bopindolol, bevantolol, ephedra, formoterol, pirbuterol, pindolol, asenapine, norepinephrine, sotalol, bupranolol, nadolol, phenoxybenzamine, droxidopa, carvedilol, dobutamine, metipranolol, pseudoephedrine, salmeterol, dipivefrin, indacaterol, terbutaline, salbutamol.
  16.  
Beta-3 adrenergic receptor P13945/ADRB3_HUMAN
  Drugs:  mirabegron, bupranolol, bopindolol, norepinephrine, fenoterol, clenbuterol, droxidopa, propranolol, ephedra, isoproterenol, arbutamine.
  17.  
C-C chemokine receptor type 5 P51681/CCR5_HUMAN
  Drugs:  maraviroc.
  18.  
C-X-C chemokine receptor type 4 P61073/CXCR4_HUMAN
  Drugs:  plerixafor, framycetin.
  19.  
Calcitonin receptor P30988/CALCR_HUMAN
  Drugs:  pramlintide, salmon calcitonin.
  20.  
Cannabinoid receptor 1 P21554/CNR1_HUMAN
  Drugs:  rimonabant, dronabinol, nabilone.

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