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Analysis of drug targets by Gene Ontology

The analysis below shows the distributions of drug targets across the main classes of the Gene Ontology (GO). Click on the link to see a list of protein targets belonging to each class.

Note that, not all the targets defined in DrugBank have an associated UniProt code and, of those that do, not all have been classified in GO.

1. Cellular component

Link   GO class No. of targets
  1.   membrane 586   (38.6%)
  2.   cytoplasm 220   (14.5%)
  3.   extracellular region 209   (13.8%)
  4.   synapse 67   (4.4%)
  5.   mitochondrion 58   (3.8%)
  6.   cell surface 53   (3.5%)
  7.   intracellular 48   (3.2%)
  8.   extracellular space 34   (2.2%)
  9.   cytosol 32   (2.1%)
  10.   nucleus 27   (1.8%)
  ...   + 60 others 212   (14.0%)

2. Biological process

Link   GO class No. of targets
  1.   transport 243   (15.3%)
  2.   metabolic process 218   (13.7%)
  3.   signal transduction 74   (4.7%)
  4.   oxidation reduction 61   (3.8%)
  5.   cellular metabolic process 60   (3.8%)
  6.   viral reproduction 51   (3.2%)
  7.   immune system process 46   (2.9%)
  8.   gene expression 34   (2.1%)
  9.   immune response 32   (2.0%)
  10.   lipid metabolic process 32   (2.0%)
  ...   + 231 others 772   (48.5%)

3. Molecular function

Link   GO class No. of targets
  1.   protein binding 300   (18.9%)
  2.   catalytic activity 209   (13.2%)
  3.   nucleotide binding 205   (12.9%)
  4.   signal transducer activity 132   (8.3%)
  5.   oxidoreductase activity 125   (7.9%)
  6.   hydrolase activity 86   (5.4%)
  7.   transferase activity 66   (4.2%)
  8.   transporter activity 45   (2.8%)
  9.   electron carrier activity 33   (2.1%)
  10.   ion channel activity 28   (1.8%)
  11.   symporter activity 22   (1.4%)
  12.   structural constituent of ribosome 19   (1.2%)
  13.   lyase activity 16   (1.0%)
  14.   structural molecule activity 16   (1.0%)
  15.   NADH dehydrogenase (ubiquinone) activity 15   (0.9%)
  16.   penicillin binding 15   (0.9%)
  17.   receptor activity 12   (0.8%)
  18.   drug binding 12   (0.8%)
  19.   chromatin binding 11   (0.7%)
  20.   metal ion binding 10   (0.6%)
  21.   receptor binding 9   (0.6%)
  22.   nucleic acid binding 6   (0.4%)
  23.   voltage\-gated ion channel activity 6   (0.4%)
  24.   enzyme inhibitor activity 6   (0.4%)
  25.   GABA\-A receptor activity 6   (0.4%)
  26.   acetylcholine receptor activity 5   (0.3%)
  27.   peptidase inhibitor activity 5   (0.3%)
  28.   cytokine activity 5   (0.3%)
  29.   DNA binding 5   (0.3%)
  30.   isomerase activity 5   (0.3%)
  31.   extracellular matrix structural constituent 5   (0.3%)
  32.   enzyme activator activity 4   (0.3%)
  33.   benzodiazepine receptor activity 4   (0.3%)
  34.   amino acid transmembrane transporter activity 4   (0.3%)
  35.   acetylcholine binding 4   (0.3%)
  36.   sodium channel regulator activity 4   (0.3%)
  37.   calmodulin binding 4   (0.3%)
  38.   enzyme regulator activity 4   (0.3%)
  39.   transmembrane receptor activity 3   (0.2%)
  40.   lipid binding 3   (0.2%)
  41.   protein C\-terminus binding 3   (0.2%)
  42.   potassium channel regulator activity 3   (0.2%)
  43.   selenium binding 3   (0.2%)
  44.   IgG binding 3   (0.2%)
  45.   antioxidant activity 3   (0.2%)
  46.   NADH dehydrogenase activity 3   (0.2%)
  47.   antigen binding 3   (0.2%)
  48.   protease binding 3   (0.2%)
  49.   carbohydrate binding 3   (0.2%)
  50.   peptidase activity 2   (0.1%)
  51.   cytokine receptor activity 2   (0.1%)
  52.   fibronectin binding 2   (0.1%)
  53.   protein homodimerization activity 2   (0.1%)
  54.   monooxygenase activity 2   (0.1%)
  55.   IgE binding 2   (0.1%)
  56.   L\-ornithine transmembrane transporter activity 2   (0.1%)
  57.   peptide antigen binding 2   (0.1%)
  58.   hormone activity 2   (0.1%)
  59.   sulfonylurea receptor binding 2   (0.1%)
  60.   toxin binding 2   (0.1%)
  61.   channel activity 2   (0.1%)
  62.   folic acid binding 2   (0.1%)
  63.   oxidoreductase activity\, acting on NADH or NADPH 2   (0.1%)
  64.   glycine binding 2   (0.1%)
  65.   carboxypeptidase activity 2   (0.1%)
  66.   protein complex binding 2   (0.1%)
  67.   ankyrin binding 2   (0.1%)
  68.   integrin binding 2   (0.1%)
  69.   protein domain specific binding 1   (0.1%)
  70.   aminoacylase activity 1   (0.1%)
  71.   potassium channel inhibitor activity 1   (0.1%)
  72.   retinoid binding 1   (0.1%)
  73.   kinesin binding 1   (0.1%)
  74.   viral receptor activity 1   (0.1%)
  75.   MHC class II receptor activity 1   (0.1%)
  76.   pyridoxal phosphate binding 1   (0.1%)
  77.   dihydropteroate synthase activity 1   (0.1%)
  78.   tRNA binding 1   (0.1%)
  79.   thiamin uptake transmembrane transporter activity 1   (0.1%)
  80.   carbonate dehydratase activity 1   (0.1%)
  81.   threonine synthase activity 1   (0.1%)
  82.   interleukin\-2 binding 1   (0.1%)
  83.   structural constituent of cytoskeleton 1   (0.1%)
  84.   immunoglobulin receptor activity 1   (0.1%)
  85.   enzyme binding 1   (0.1%)
  86.   RNA binding 1   (0.1%)
  87.   transcription coactivator activity 1   (0.1%)
  88.   cobalamin binding 1   (0.1%)
  89.   hyaluronic acid binding 1   (0.1%)
  90.   drug transporter activity 1   (0.1%)
  91.   creatine transporter activity 1   (0.1%)
  92.   ATP binding 1   (0.1%)
  93.   glutamate binding 1   (0.1%)
  94.   acyl carrier activity 1   (0.1%)
  95.   tubulin binding 1   (0.1%)
  96.   calcium ion binding 1   (0.1%)
  97.   growth factor activity 1   (0.1%)
  98.   complement component C1q binding 1   (0.1%)
  99.   complement binding 1   (0.1%)
  100.   translation repressor activity\, nucleic acid binding 1   (0.1%)
  101.   L\-cystine transmembrane transporter activity 1   (0.1%)
  102.   peptide YY receptor activity 1   (0.1%)
  103.   endopeptidase inhibitor activity 1   (0.1%)
  104.   protein kinase binding 1   (0.1%)
  105.   extracellular matrix binding 1   (0.1%)
  106.   GABA receptor binding 1   (0.1%)
  107.   voltage\-gated calcium channel activity 1   (0.1%)
  108.   neurotransmitter transporter activity 1   (0.1%)
  109.   peptide hormone binding 1   (0.1%)
  110.   acyl carnitine transporter activity 1   (0.1%)
  111.   androgen binding 1   (0.1%)
  112.   epidermal growth factor receptor binding 1   (0.1%)
  113.   triacylglycerol lipase activity 1   (0.1%)
  114.   receptor signaling complex scaffold activity 1   (0.1%)
  115.   neurotransmitter binding 1   (0.1%)
  116.   G\-protein alpha\-subunit binding 1   (0.1%)
  117.   amino acid binding 1   (0.1%)

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