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Analysis of drug targets by Gene Ontology

The analysis below shows the distributions of drug targets across the main classes of the Gene Ontology (GO). Click on the link to see a list of protein targets belonging to each class.

Note that, not all the targets defined in DrugBank have an associated UniProt code and, of those that do, not all have been classified in GO.

1. Cellular component

Link   GO class No. of targets
  1.   membrane 584   (38.4%)
  2.   cytoplasm 222   (14.6%)
  3.   extracellular region 209   (13.8%)
  4.   synapse 67   (4.4%)
  5.   mitochondrion 55   (3.6%)
  6.   cell surface 52   (3.4%)
  7.   intracellular 49   (3.2%)
  8.   extracellular space 33   (2.2%)
  9.   cytosol 33   (2.2%)
  10.   nucleus 32   (2.1%)
  ...   + 57 others 215   (14.2%)

2. Biological process

Link   GO class No. of targets
  1.   transport 239   (15.1%)
  2.   metabolic process 215   (13.5%)
  3.   signal transduction 74   (4.7%)
  4.   cellular metabolic process 62   (3.9%)
  5.   oxidation reduction 61   (3.8%)
  6.   viral reproduction 51   (3.2%)
  7.   immune system process 43   (2.7%)
  8.   lipid metabolic process 34   (2.1%)
  9.   cellular nitrogen compound metabolic process 32   (2.0%)
  10.   gene expression 32   (2.0%)
  ...   + 233 others 777   (48.9%)

3. Molecular function

Link   GO class No. of targets
  1.   protein binding 288   (18.1%)
  2.   catalytic activity 211   (13.3%)
  3.   nucleotide binding 206   (13.0%)
  4.   signal transducer activity 132   (8.3%)
  5.   oxidoreductase activity 126   (7.9%)
  6.   hydrolase activity 86   (5.4%)
  7.   transferase activity 68   (4.3%)
  8.   transporter activity 53   (3.3%)
  9.   electron carrier activity 33   (2.1%)
  10.   ion channel activity 29   (1.8%)
  11.   symporter activity 21   (1.3%)
  12.   structural constituent of ribosome 20   (1.3%)
  13.   structural molecule activity 16   (1.0%)
  14.   lyase activity 16   (1.0%)
  15.   NADH dehydrogenase (ubiquinone) activity 15   (0.9%)
  16.   penicillin binding 15   (0.9%)
  17.   drug binding 14   (0.9%)
  18.   receptor activity 10   (0.6%)
  19.   metal ion binding 10   (0.6%)
  20.   receptor binding 9   (0.6%)
  21.   chromatin binding 9   (0.6%)
  22.   enzyme inhibitor activity 7   (0.4%)
  23.   GABA\-A receptor activity 6   (0.4%)
  24.   voltage\-gated ion channel activity 6   (0.4%)
  25.   benzodiazepine receptor activity 5   (0.3%)
  26.   nucleic acid binding 5   (0.3%)
  27.   extracellular matrix structural constituent 5   (0.3%)
  28.   isomerase activity 5   (0.3%)
  29.   acetylcholine receptor activity 5   (0.3%)
  30.   DNA binding 5   (0.3%)
  31.   peptidase inhibitor activity 5   (0.3%)
  32.   enzyme activator activity 4   (0.3%)
  33.   calmodulin binding 4   (0.3%)
  34.   sodium channel regulator activity 4   (0.3%)
  35.   cytokine activity 4   (0.3%)
  36.   acetylcholine binding 4   (0.3%)
  37.   protein C\-terminus binding 3   (0.2%)
  38.   carbohydrate binding 3   (0.2%)
  39.   enzyme regulator activity 3   (0.2%)
  40.   peptide antigen binding 3   (0.2%)
  41.   IgG binding 3   (0.2%)
  42.   transmembrane receptor activity 3   (0.2%)
  43.   protease binding 3   (0.2%)
  44.   selenium binding 3   (0.2%)
  45.   antioxidant activity 3   (0.2%)
  46.   NADH dehydrogenase activity 3   (0.2%)
  47.   lipid binding 3   (0.2%)
  48.   potassium channel regulator activity 3   (0.2%)
  49.   amino acid transmembrane transporter activity 3   (0.2%)
  50.   cobalamin binding 2   (0.1%)
  51.   hormone activity 2   (0.1%)
  52.   channel activity 2   (0.1%)
  53.   ankyrin binding 2   (0.1%)
  54.   carboxypeptidase activity 2   (0.1%)
  55.   protein homodimerization activity 2   (0.1%)
  56.   L\-ornithine transmembrane transporter activity 2   (0.1%)
  57.   oxidoreductase activity\, acting on NADH or NADPH 2   (0.1%)
  58.   IgE binding 2   (0.1%)
  59.   sulfonylurea receptor binding 2   (0.1%)
  60.   antigen binding 2   (0.1%)
  61.   adenyl nucleotide binding 2   (0.1%)
  62.   peptidase activity 2   (0.1%)
  63.   folic acid binding 2   (0.1%)
  64.   fibronectin binding 2   (0.1%)
  65.   monooxygenase activity 2   (0.1%)
  66.   glycine binding 2   (0.1%)
  67.   protein complex binding 2   (0.1%)
  68.   potassium channel inhibitor activity 1   (0.1%)
  69.   neurotransmitter transporter activity 1   (0.1%)
  70.   insulin\-like growth factor binding 1   (0.1%)
  71.   pyridoxal phosphate binding 1   (0.1%)
  72.   extracellular matrix binding 1   (0.1%)
  73.   complement binding 1   (0.1%)
  74.   interleukin\-2 binding 1   (0.1%)
  75.   receptor signaling protein activity 1   (0.1%)
  76.   complement component C1q binding 1   (0.1%)
  77.   interferon\-gamma receptor activity 1   (0.1%)
  78.   creatine transporter activity 1   (0.1%)
  79.   interleukin\-1 receptor binding 1   (0.1%)
  80.   translation repressor activity\, nucleic acid binding 1   (0.1%)
  81.   glutamate\-cysteine ligase catalytic subunit binding 1   (0.1%)
  82.   viral receptor activity 1   (0.1%)
  83.   peptide YY receptor activity 1   (0.1%)
  84.   dihydropteroate synthase activity 1   (0.1%)
  85.   immunoglobulin receptor activity 1   (0.1%)
  86.   thiamin uptake transmembrane transporter activity 1   (0.1%)
  87.   MHC class II receptor activity 1   (0.1%)
  88.   transcription coactivator activity 1   (0.1%)
  89.   aminoacylase activity 1   (0.1%)
  90.   L\-cystine transmembrane transporter activity 1   (0.1%)
  91.   drug transporter activity 1   (0.1%)
  92.   amino acid binding 1   (0.1%)
  93.   hyaluronic acid binding 1   (0.1%)
  94.   glutamate binding 1   (0.1%)
  95.   acyl carrier activity 1   (0.1%)
  96.   receptor signaling complex scaffold activity 1   (0.1%)
  97.   carbonate dehydratase activity 1   (0.1%)
  98.   ATP binding 1   (0.1%)
  99.   integrin binding 1   (0.1%)
  100.   enzyme binding 1   (0.1%)
  101.   calcium ion binding 1   (0.1%)
  102.   RNA binding 1   (0.1%)
  103.   toxin binding 1   (0.1%)
  104.   glycine transmembrane transporter activity 1   (0.1%)
  105.   endopeptidase inhibitor activity 1   (0.1%)
  106.   protein kinase binding 1   (0.1%)
  107.   GABA receptor binding 1   (0.1%)
  108.   protein domain specific binding 1   (0.1%)
  109.   voltage\-gated calcium channel activity 1   (0.1%)
  110.   cytokine receptor activity 1   (0.1%)
  111.   peptide hormone binding 1   (0.1%)
  112.   retinoid binding 1   (0.1%)
  113.   growth factor activity 1   (0.1%)
  114.   epidermal growth factor receptor binding 1   (0.1%)
  115.   triacylglycerol lipase activity 1   (0.1%)
  116.   structural constituent of cytoskeleton 1   (0.1%)
  117.   acyl carnitine transporter activity 1   (0.1%)
  118.   G\-protein alpha\-subunit binding 1   (0.1%)

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