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Analysis of drug targets by Gene Ontology

The analysis below shows the distributions of drug targets across the main classes of the Gene Ontology (GO). Click on the link to see a list of protein targets belonging to each class.

Note that, not all the targets defined in DrugBank have an associated UniProt code and, of those that do, not all have been classified in GO.

1. Cellular component

Link   GO class No. of targets
  1.   membrane 594   (39.2%)
  2.   cytoplasm 224   (14.8%)
  3.   extracellular region 209   (13.8%)
  4.   synapse 68   (4.5%)
  5.   mitochondrion 55   (3.6%)
  6.   intracellular 50   (3.3%)
  7.   cell surface 46   (3.0%)
  8.   extracellular space 34   (2.2%)
  9.   cytosol 34   (2.2%)
  10.   nucleus 33   (2.2%)
  ...   + 54 others 201   (13.3%)

2. Biological process

Link   GO class No. of targets
  1.   transport 236   (14.9%)
  2.   metabolic process 219   (13.8%)
  3.   signal transduction 71   (4.5%)
  4.   cellular metabolic process 64   (4.0%)
  5.   oxidation reduction 62   (3.9%)
  6.   viral reproduction 51   (3.2%)
  7.   immune system process 43   (2.7%)
  8.   lipid metabolic process 33   (2.1%)
  9.   cellular nitrogen compound metabolic process 33   (2.1%)
  10.   immune response 32   (2.0%)
  ...   + 230 others 776   (48.9%)

3. Molecular function

Link   GO class No. of targets
  1.   protein binding 285   (18.0%)
  2.   catalytic activity 227   (14.3%)
  3.   nucleotide binding 202   (12.7%)
  4.   signal transducer activity 130   (8.2%)
  5.   oxidoreductase activity 126   (7.9%)
  6.   hydrolase activity 79   (5.0%)
  7.   transferase activity 66   (4.2%)
  8.   transporter activity 53   (3.3%)
  9.   electron carrier activity 34   (2.1%)
  10.   ion channel activity 29   (1.8%)
  11.   symporter activity 21   (1.3%)
  12.   structural constituent of ribosome 20   (1.3%)
  13.   lyase activity 16   (1.0%)
  14.   structural molecule activity 16   (1.0%)
  15.   NADH dehydrogenase (ubiquinone) activity 15   (0.9%)
  16.   penicillin binding 15   (0.9%)
  17.   drug binding 14   (0.9%)
  18.   metal ion binding 10   (0.6%)
  19.   receptor activity 10   (0.6%)
  20.   chromatin binding 9   (0.6%)
  21.   receptor binding 9   (0.6%)
  22.   enzyme inhibitor activity 7   (0.4%)
  23.   voltage\-gated ion channel activity 6   (0.4%)
  24.   GABA\-A receptor activity 6   (0.4%)
  25.   isomerase activity 5   (0.3%)
  26.   peptidase inhibitor activity 5   (0.3%)
  27.   extracellular matrix structural constituent 5   (0.3%)
  28.   nucleic acid binding 5   (0.3%)
  29.   acetylcholine receptor activity 5   (0.3%)
  30.   DNA binding 5   (0.3%)
  31.   sodium channel regulator activity 4   (0.3%)
  32.   benzodiazepine receptor activity 4   (0.3%)
  33.   acetylcholine binding 4   (0.3%)
  34.   enzyme activator activity 4   (0.3%)
  35.   cytokine activity 4   (0.3%)
  36.   calmodulin binding 4   (0.3%)
  37.   lipid binding 3   (0.2%)
  38.   peptide antigen binding 3   (0.2%)
  39.   amino acid transmembrane transporter activity 3   (0.2%)
  40.   selenium binding 3   (0.2%)
  41.   protease binding 3   (0.2%)
  42.   carbohydrate binding 3   (0.2%)
  43.   NADH dehydrogenase activity 3   (0.2%)
  44.   protein C\-terminus binding 3   (0.2%)
  45.   antioxidant activity 3   (0.2%)
  46.   protein complex binding 3   (0.2%)
  47.   IgG binding 3   (0.2%)
  48.   potassium channel regulator activity 3   (0.2%)
  49.   transmembrane receptor activity 3   (0.2%)
  50.   enzyme regulator activity 3   (0.2%)
  51.   monooxygenase activity 2   (0.1%)
  52.   oxidoreductase activity\, acting on NADH or NADPH 2   (0.1%)
  53.   channel activity 2   (0.1%)
  54.   antigen binding 2   (0.1%)
  55.   hormone activity 2   (0.1%)
  56.   adenyl nucleotide binding 2   (0.1%)
  57.   ankyrin binding 2   (0.1%)
  58.   glycine binding 2   (0.1%)
  59.   protein homodimerization activity 2   (0.1%)
  60.   carboxypeptidase activity 2   (0.1%)
  61.   sulfonylurea receptor binding 2   (0.1%)
  62.   L\-ornithine transmembrane transporter activity 2   (0.1%)
  63.   folic acid binding 2   (0.1%)
  64.   cobalamin binding 2   (0.1%)
  65.   IgE binding 2   (0.1%)
  66.   peptidase activity 2   (0.1%)
  67.   GABA receptor binding 1   (0.1%)
  68.   pyridoxal phosphate binding 1   (0.1%)
  69.   immunoglobulin receptor activity 1   (0.1%)
  70.   hyaluronic acid binding 1   (0.1%)
  71.   complement component C1q binding 1   (0.1%)
  72.   interleukin\-2 binding 1   (0.1%)
  73.   peptide YY receptor activity 1   (0.1%)
  74.   aminoacylase activity 1   (0.1%)
  75.   glutamate\-cysteine ligase catalytic subunit binding 1   (0.1%)
  76.   translation repressor activity\, nucleic acid binding 1   (0.1%)
  77.   structural constituent of cytoskeleton 1   (0.1%)
  78.   acyl carrier activity 1   (0.1%)
  79.   dihydropteroate synthase activity 1   (0.1%)
  80.   L\-cystine transmembrane transporter activity 1   (0.1%)
  81.   RNA binding 1   (0.1%)
  82.   transcription coactivator activity 1   (0.1%)
  83.   receptor signaling complex scaffold activity 1   (0.1%)
  84.   peptide hormone binding 1   (0.1%)
  85.   interleukin\-1 receptor binding 1   (0.1%)
  86.   thiamin uptake transmembrane transporter activity 1   (0.1%)
  87.   MHC class II receptor activity 1   (0.1%)
  88.   thymidylate synthase activity 1   (0.1%)
  89.   acyl carnitine transporter activity 1   (0.1%)
  90.   calcium ion binding 1   (0.1%)
  91.   carbonate dehydratase activity 1   (0.1%)
  92.   interferon\-gamma receptor activity 1   (0.1%)
  93.   enzyme binding 1   (0.1%)
  94.   receptor signaling protein activity 1   (0.1%)
  95.   drug transporter activity 1   (0.1%)
  96.   phosphotransferase activity\, alcohol group as acceptor 1   (0.1%)
  97.   amino acid binding 1   (0.1%)
  98.   creatine transporter activity 1   (0.1%)
  99.   glutamate binding 1   (0.1%)
  100.   complement binding 1   (0.1%)
  101.   integrin binding 1   (0.1%)
  102.   growth factor activity 1   (0.1%)
  103.   fibronectin binding 1   (0.1%)
  104.   viral receptor activity 1   (0.1%)
  105.   potassium channel inhibitor activity 1   (0.1%)
  106.   extracellular matrix binding 1   (0.1%)
  107.   glycine transmembrane transporter activity 1   (0.1%)
  108.   endopeptidase inhibitor activity 1   (0.1%)
  109.   protein kinase binding 1   (0.1%)
  110.   cytokine receptor activity 1   (0.1%)
  111.   retinoid binding 1   (0.1%)
  112.   voltage\-gated calcium channel activity 1   (0.1%)
  113.   protein domain specific binding 1   (0.1%)
  114.   neurotransmitter transporter activity 1   (0.1%)
  115.   epidermal growth factor receptor binding 1   (0.1%)
  116.   insulin\-like growth factor binding 1   (0.1%)
  117.   androgen binding 1   (0.1%)
  118.   argininosuccinate synthase activity 1   (0.1%)
  119.   triacylglycerol lipase activity 1   (0.1%)
  120.   G\-protein alpha\-subunit binding 1   (0.1%)

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