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Analysis of drug targets by Gene Ontology

The analysis below shows the distributions of drug targets across the main classes of the Gene Ontology (GO). Click on the link to see a list of protein targets belonging to each class.

Note that, not all the targets defined in DrugBank have an associated UniProt code and, of those that do, not all have been classified in GO.

1. Cellular component

Link   GO class No. of targets
  1.   membrane 594   (39.2%)
  2.   cytoplasm 224   (14.8%)
  3.   extracellular region 209   (13.8%)
  4.   synapse 68   (4.5%)
  5.   mitochondrion 55   (3.6%)
  6.   intracellular 50   (3.3%)
  7.   cell surface 46   (3.0%)
  8.   extracellular space 34   (2.2%)
  9.   cytosol 34   (2.2%)
  10.   nucleus 33   (2.2%)
  11.   plasma membrane 20   (1.3%)
  12.   protein complex 20   (1.3%)
  13.   intracellular membrane\-bounded organelle 10   (0.7%)
  14.   virion 10   (0.7%)
  15.   ribonucleoprotein complex 8   (0.5%)
  16.   endomembrane system 6   (0.4%)
  17.   periplasmic space 6   (0.4%)
  18.   extracellular vesicular exosome 6   (0.4%)
  19.   asymmetric synapse 5   (0.3%)
  20.   proteasome complex 5   (0.3%)
  21.   host cell nucleus 5   (0.3%)
  22.   nuclear chromatin 5   (0.3%)
  23.   endoplasmic reticulum 4   (0.3%)
  24.   cell soma 4   (0.3%)
  25.   neuromuscular junction 2   (0.1%)
  26.   DNA topoisomerase complex (ATP\-hydrolyzing) 2   (0.1%)
  27.   protein phosphatase type 2A complex 2   (0.1%)
  28.   vesicle 2   (0.1%)
  29.   cell leading edge 2   (0.1%)
  30.   cilium 2   (0.1%)
  31.   perikaryon 2   (0.1%)
  32.   neuron projection 2   (0.1%)
  33.   Golgi membrane 2   (0.1%)
  34.   integral to membrane 2   (0.1%)
  35.   photoreceptor inner segment 2   (0.1%)
  36.   cell projection 2   (0.1%)
  37.   chromatin 2   (0.1%)
  38.   pseudopodium 2   (0.1%)
  39.   vacuole 1   (0.1%)
  40.   glutamate\-cysteine ligase complex 1   (0.1%)
  41.   nuclear chromosome 1   (0.1%)
  42.   glutamyl\-tRNA(Gln) amidotransferase complex 1   (0.1%)
  43.   membrane\-bounded vesicle 1   (0.1%)
  44.   voltage\-gated sodium channel complex 1   (0.1%)
  45.   peroxisome 1   (0.1%)
  46.   midbody 1   (0.1%)
  47.   host cell cytoplasm 1   (0.1%)
  48.   photoreceptor outer segment 1   (0.1%)
  49.   cell wall 1   (0.1%)
  50.   intracellular ferritin complex 1   (0.1%)
  51.   basement membrane 1   (0.1%)
  52.   pilus 1   (0.1%)
  53.   motile secondary cilium 1   (0.1%)
  54.   extracellular matrix 1   (0.1%)
  55.   viral envelope 1   (0.1%)
  56.   beta\-galactosidase complex 1   (0.1%)
  57.   macromolecular complex 1   (0.1%)
  58.   glycine cleavage complex 1   (0.1%)
  59.   cyclin\-dependent protein kinase holoenzyme complex 1   (0.1%)
  60.   voltage\-gated calcium channel complex 1   (0.1%)
  61.   chromosome 1   (0.1%)
  62.   I\-kappaB/NF\-kappaB complex 1   (0.1%)
  63.   lysosome 1   (0.1%)
  64.   AMP\-activated protein kinase complex 1   (0.1%)

2. Biological process

Link   GO class No. of targets
  1.   transport 236   (14.9%)
  2.   metabolic process 219   (13.8%)
  3.   signal transduction 71   (4.5%)
  4.   cellular metabolic process 64   (4.0%)
  5.   oxidation reduction 62   (3.9%)
  6.   viral reproduction 51   (3.2%)
  7.   immune system process 43   (2.7%)
  8.   lipid metabolic process 33   (2.1%)
  9.   cellular nitrogen compound metabolic process 33   (2.1%)
  10.   immune response 32   (2.0%)
  ...   + 230 others 776   (48.9%)

3. Molecular function

Link   GO class No. of targets
  1.   protein binding 285   (18.0%)
  2.   catalytic activity 227   (14.3%)
  3.   nucleotide binding 202   (12.7%)
  4.   signal transducer activity 130   (8.2%)
  5.   oxidoreductase activity 126   (7.9%)
  6.   hydrolase activity 79   (5.0%)
  7.   transferase activity 66   (4.2%)
  8.   transporter activity 53   (3.3%)
  9.   electron carrier activity 34   (2.1%)
  10.   ion channel activity 29   (1.8%)
  ...   + 110 others 385   (24.3%)

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