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Analysis of drug targets by Gene Ontology

The analysis below shows the distributions of drug targets across the main classes of the Gene Ontology (GO). Click on the link to see a list of protein targets belonging to each class.

Note that, not all the targets defined in DrugBank have an associated UniProt code and, of those that do, not all have been classified in GO.

1. Cellular component

Link   GO class No. of targets
  1.   membrane 586   (38.6%)
  2.   cytoplasm 222   (14.6%)
  3.   extracellular region 208   (13.7%)
  4.   synapse 67   (4.4%)
  5.   mitochondrion 58   (3.8%)
  6.   cell surface 53   (3.5%)
  7.   intracellular 49   (3.2%)
  8.   extracellular space 34   (2.2%)
  9.   cytosol 32   (2.1%)
  10.   nucleus 26   (1.7%)
  11.   plasma membrane 24   (1.6%)
  12.   protein complex 20   (1.3%)
  13.   intracellular membrane\-bounded organelle 11   (0.7%)
  14.   vesicle 10   (0.7%)
  15.   virion 10   (0.7%)
  16.   extracellular vesicular exosome 8   (0.5%)
  17.   ribonucleoprotein complex 7   (0.5%)
  18.   endomembrane system 6   (0.4%)
  19.   periplasmic space 6   (0.4%)
  20.   cell soma 6   (0.4%)
  21.   nuclear chromatin 5   (0.3%)
  22.   proteasome complex 5   (0.3%)
  23.   host cell nucleus 4   (0.3%)
  24.   endoplasmic reticulum 4   (0.3%)
  25.   asymmetric synapse 3   (0.2%)
  26.   chromatin 3   (0.2%)
  27.   cilium 3   (0.2%)
  28.   host cell cytoplasm 2   (0.1%)
  29.   neuromuscular junction 2   (0.1%)
  30.   glutamate\-cysteine ligase complex 2   (0.1%)
  31.   photoreceptor inner segment 2   (0.1%)
  32.   cell projection 2   (0.1%)
  33.   Golgi membrane 2   (0.1%)
  34.   pseudopodium 2   (0.1%)
  35.   DNA topoisomerase complex (ATP\-hydrolyzing) 2   (0.1%)
  36.   protein phosphatase type 2A complex 2   (0.1%)
  37.   photoreceptor outer segment 1   (0.1%)
  38.   myelin sheath 1   (0.1%)
  39.   histone deacetylase complex 1   (0.1%)
  40.   macromolecular complex 1   (0.1%)
  41.   I\-kappaB/NF\-kappaB complex 1   (0.1%)
  42.   extracellular matrix 1   (0.1%)
  43.   vacuole 1   (0.1%)
  44.   voltage\-gated sodium channel complex 1   (0.1%)
  45.   chromosome 1   (0.1%)
  46.   motile secondary cilium 1   (0.1%)
  47.   lysosome 1   (0.1%)
  48.   chromosome\, telomeric region 1   (0.1%)
  49.   midbody 1   (0.1%)
  50.   glycine cleavage complex 1   (0.1%)
  51.   receptor complex 1   (0.1%)
  52.   intracellular ferritin complex 1   (0.1%)
  53.   perikaryon 1   (0.1%)
  54.   cytoplasmic mRNA processing body 1   (0.1%)
  55.   cell wall 1   (0.1%)
  56.   viral envelope 1   (0.1%)
  57.   pilus 1   (0.1%)
  58.   neuron projection 1   (0.1%)
  59.   peroxisome 1   (0.1%)
  60.   integral to membrane 1   (0.1%)
  61.   glutamyl\-tRNA(Gln) amidotransferase complex 1   (0.1%)
  62.   voltage\-gated calcium channel complex 1   (0.1%)
  63.   cyclin\-dependent protein kinase holoenzyme complex 1   (0.1%)
  64.   basement membrane 1   (0.1%)
  65.   nuclear chromosome 1   (0.1%)
  66.   AMP\-activated protein kinase complex 1   (0.1%)
  67.   beta\-galactosidase complex 1   (0.1%)

2. Biological process

Link   GO class No. of targets
  1.   transport 247   (15.5%)
  2.   metabolic process 215   (13.5%)
  3.   signal transduction 73   (4.6%)
  4.   cellular metabolic process 61   (3.8%)
  5.   oxidation reduction 61   (3.8%)
  6.   viral reproduction 51   (3.2%)
  7.   immune system process 46   (2.9%)
  8.   lipid metabolic process 34   (2.1%)
  9.   gene expression 34   (2.1%)
  10.   cell adhesion 32   (2.0%)
  ...   + 231 others 768   (48.3%)

3. Molecular function

Link   GO class No. of targets
  1.   protein binding 294   (18.5%)
  2.   catalytic activity 211   (13.3%)
  3.   nucleotide binding 206   (13.0%)
  4.   signal transducer activity 132   (8.3%)
  5.   oxidoreductase activity 125   (7.9%)
  6.   hydrolase activity 85   (5.4%)
  7.   transferase activity 66   (4.2%)
  8.   transporter activity 53   (3.3%)
  9.   electron carrier activity 33   (2.1%)
  10.   ion channel activity 28   (1.8%)
  ...   + 104 others 381   (24.0%)

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