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Analysis of drug targets by Gene Ontology

The analysis below shows the distributions of drug targets across the main classes of the Gene Ontology (GO). Click on the link to see a list of protein targets belonging to each class.

Note that, not all the targets defined in DrugBank have an associated UniProt code and, of those that do, not all have been classified in GO.

1. Cellular component

Link   GO class No. of targets
  1.   membrane 571   (37.6%)
  2.   cytoplasm 231   (15.2%)
  3.   extracellular region 211   (13.9%)
  4.   synapse 68   (4.5%)
  5.   mitochondrion 65   (4.3%)
  6.   intracellular 50   (3.3%)
  7.   cell surface 44   (2.9%)
  8.   cytosol 37   (2.4%)
  9.   extracellular space 32   (2.1%)
  10.   nucleus 29   (1.9%)
  11.   plasma membrane 25   (1.6%)
  12.   protein complex 22   (1.4%)
  13.   intracellular membrane\-bounded organelle 12   (0.8%)
  14.   virion 10   (0.7%)
  15.   ribonucleoprotein complex 9   (0.6%)
  16.   proteasome complex 8   (0.5%)
  17.   periplasmic space 6   (0.4%)
  18.   endomembrane system 6   (0.4%)
  19.   asymmetric synapse 5   (0.3%)
  20.   host cell nucleus 5   (0.3%)
  21.   endoplasmic reticulum 5   (0.3%)
  22.   cell soma 4   (0.3%)
  23.   extracellular vesicular exosome 4   (0.3%)
  24.   nuclear chromatin 4   (0.3%)
  25.   cell wall 3   (0.2%)
  26.   cilium 3   (0.2%)
  27.   Golgi membrane 2   (0.1%)
  28.   integral to membrane 2   (0.1%)
  29.   neuron projection 2   (0.1%)
  30.   chromatin 2   (0.1%)
  31.   photoreceptor inner segment 2   (0.1%)
  32.   perikaryon 2   (0.1%)
  33.   vesicle 2   (0.1%)
  34.   protein phosphatase type 2A complex 2   (0.1%)
  35.   cell projection 2   (0.1%)
  36.   cell leading edge 2   (0.1%)
  37.   neuromuscular junction 2   (0.1%)
  38.   intracellular ferritin complex 2   (0.1%)
  39.   pseudopodium 2   (0.1%)
  40.   chromosome 1   (0.1%)
  41.   cyclin\-dependent protein kinase holoenzyme complex 1   (0.1%)
  42.   midbody 1   (0.1%)
  43.   macromolecular complex 1   (0.1%)
  44.   I\-kappaB/NF\-kappaB complex 1   (0.1%)
  45.   peroxisome 1   (0.1%)
  46.   nuclear chromosome 1   (0.1%)
  47.   glutamyl\-tRNA(Gln) amidotransferase complex 1   (0.1%)
  48.   lysosome 1   (0.1%)
  49.   extracellular matrix 1   (0.1%)
  50.   photoreceptor outer segment 1   (0.1%)
  51.   AMP\-activated protein kinase complex 1   (0.1%)
  52.   glutamate\-cysteine ligase complex 1   (0.1%)
  53.   membrane\-bounded vesicle 1   (0.1%)
  54.   basement membrane 1   (0.1%)
  55.   pilus 1   (0.1%)
  56.   viral envelope 1   (0.1%)
  57.   voltage\-gated calcium channel complex 1   (0.1%)
  58.   DNA topoisomerase complex (ATP\-hydrolyzing) 1   (0.1%)
  59.   beta\-galactosidase complex 1   (0.1%)
  60.   motile secondary cilium 1   (0.1%)
  61.   voltage\-gated sodium channel complex 1   (0.1%)
  62.   glycine cleavage complex 1   (0.1%)
  63.   vacuole 1   (0.1%)

2. Biological process

Link   GO class No. of targets
  1.   transport 236   (14.8%)
  2.   metabolic process 224   (14.1%)
  3.   signal transduction 71   (4.5%)
  4.   oxidation reduction 64   (4.0%)
  5.   cellular metabolic process 64   (4.0%)
  6.   viral reproduction 52   (3.3%)
  7.   immune system process 43   (2.7%)
  8.   gene expression 34   (2.1%)
  9.   lipid metabolic process 33   (2.1%)
  10.   cellular nitrogen compound metabolic process 33   (2.1%)
  ...   + 224 others 772   (48.5%)

3. Molecular function

Link   GO class No. of targets
  1.   protein binding 283   (17.8%)
  2.   catalytic activity 229   (14.4%)
  3.   nucleotide binding 204   (12.8%)
  4.   signal transducer activity 130   (8.2%)
  5.   oxidoreductase activity 128   (8.0%)
  6.   hydrolase activity 80   (5.0%)
  7.   transferase activity 72   (4.5%)
  8.   transporter activity 53   (3.3%)
  9.   electron carrier activity 34   (2.1%)
  10.   ion channel activity 29   (1.8%)
  ...   + 108 others 379   (23.8%)

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