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DB08910 : pomalidomide

Approved drug pomalidomide ... 3 targets DB08910

Generic name: pomalidomide
 
Brand name(s): pomalyst.
Formula: C13H11N3O4
IUPAC Formula: 4-Amino-2-(2,6-Dioxopiperidin-3-Yl)-2,3-Dihydro-1h-Isoindole-1,3-Dione

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q96SW2 (CRBN_HUMAN)  -  Protein cereblon
UniProt id: Q96SW2    441 a.a.  
4tz4 C     361 a.a. 361   X-ray 3.01 Å
There are no PDB entries containing pomalidomide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P01375 (TNFA_HUMAN)  -  Tumor necrosis factor
UniProt id: P01375    232 a.a.  
1. 1a8m A,B,C     152 a.a. 151   X-ray 2.30 Å
  2. 1tnf A,B,C     152 a.a. 151   X-ray 2.60 Å
  3. 3it8 A,B,C,G,...     152 a.a. 151   X-ray 2.80 Å
  4. 3wd5 A     152 a.a. 151   X-ray 3.10 Å
  5. 3l9j T     149 a.a. 149   X-ray 2.10 Å
   more ...
There are no PDB entries containing pomalidomide bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing pomalidomide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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