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DB08906 : fluticasone furoate

Approved drug fluticasone furoate ... 1 target DB08906

Generic name: fluticasone furoate PDB Het Group: GW6
 
1 structure in PDB
Brand name(s): avamys, veramyst.
Formula: C27H29F3O6S
IUPAC Formula: (1r,2s,8s,10s,11s,13r,14r,15s,17s)-1,8-Difluoro-14-{[(Fluoromethyl)sulfanyl]carbonyl}-17-Hydroxy-
2,13,15-Trimethyl-5-Oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadeca-3,6-Dien-14-Yl furan-2-
Carboxylate
PDB name: (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-Difluoro-17-{[(Fluoromethyl)sulfanyl]carbonyl}-11-
Hydroxy-16-Methyl-3-Oxoandrosta-1,4-Dien-17-Yl furan-2-Carboxylate

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
Links  
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Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P04150 (GCR_HUMAN)  -  Glucocorticoid receptor
UniProt id: P04150    776 a.a.  
3cld A,B   243 a.a. 241   X-ray 2.84 Å
The PDB contains 1 entry of fluticasone furoate bound to this target protein and 15 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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