spacer
spacer

Search 

DB08885 : aflibercept

Approved biotech drug aflibercept ... 3 targets DB08885

Generic name: aflibercept
No image
 
Brand name(s): eylea, zaltrap.
Formula: C4318H6788N1164O1304S32
IUPAC Formula: None

3
There are 3 target proteins defined in DrugBank for this biotech drug.
 3 
3 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank biotech drug Target 1:   UniProt id: P15692 (VEGFA_HUMAN)  -  Vascular endothelial growth factor A
UniProt id: P15692    231 a.a.  
1. 1kat V,W     99 a.a. 99   NMR  
  2. 2fjh V,W     98 a.a. 98   X-ray 3.10 Å
  3. 2vpf A,B,C,D,...     97 a.a. 97   X-ray 1.93 Å
  4. 3qtk A,D,B,C,...     96 a.a. 96   X-ray 1.85 Å
  5. 1vpp V     96 a.a. 96   X-ray 1.90 Å
   more ...
There are no PDB entries containing aflibercept bound to this target protein, although there are 29 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: P49763 (PLGF_HUMAN)  -  Placenta growth factor
UniProt id: P49763    220 a.a.  
1. 1fzv A,B     100 a.a. 97   X-ray 2.00 Å
  2. 1rv6 V,W     94 a.a. 92   X-ray 2.45 Å
There are no PDB entries containing aflibercept bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 3:   UniProt id: P49765 (VEGFB_HUMAN)  -  Vascular endothelial growth factor B
UniProt id: P49765    206 a.a.  
1. 2xac A,B     99 a.a. 99   X-ray 2.71 Å
  2. 2vwe A,B     98 a.a. 98   X-ray 3.40 Å
  3. 2c7w A,B     96 a.a. 96   X-ray 2.48 Å
There are no PDB entries containing aflibercept bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer