spacer
spacer

Search 

DB08881 : vemurafenib

Approved drug vemurafenib ... 1 target DB08881

Generic name: vemurafenib
 
Brand name(s): zelboraf.
Formula: C23H18Clf2N3O3S
IUPAC Formula: N-{3-[5-(4-Chlorophenyl)-1h-Pyrrolo[2,3-B]pyridine-3-Carbonyl]-2,4-Difluorophenyl}propane-1-
Sulfonamide

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
Links  
DrugBank
RxList
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P15056 (BRAF_HUMAN)  -  B-Raf proto-oncogene serine/threonine-protein kinase
UniProt id: P15056    765 a.a.  
1. 4e26 A,B     270 a.a. 270   X-ray 2.55 Å
  2. 4mne B,C,F,G     270 a.a. 270   X-ray 2.85 Å
  3. 4mbj A,B     269 a.a. 269   X-ray 3.60 Å
  4. 3tv6 A,B     268 a.a. 268   X-ray 3.30 Å
  5. 4pp7 A,B     267 a.a. 267   X-ray 3.40 Å
   more ...
There are no PDB entries containing vemurafenib bound to this target protein, although there are 39 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer