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DB08873 : boceprevir

Approved drug boceprevir ... 1 target DB08873

Generic name: boceprevir PDB Het Group: HU5
 
1 structure in PDB
Brand name(s): victrelis.
Formula: C27H45N5O5
IUPAC Formula: 3-{[(1r,2s,5s)-3-[(2s)-2-[(Tert-Butylcarbamoyl)amino]-3,3-Dimethylbutanoyl]-6,6-Dimethyl-3-
Azabicyclo[3.1.0]hexan-2-Yl]formamido}-4-Cyclobutyl-2-Oxobutanamide
PDB name: (1r,2s,5s)-N-[(1s)-3-Amino-1-(Cyclobutylmethyl)-2,3-Dioxopropyl]-3-[(2s)-2-{[(Tert-
Butylamino)carbonyl]amino}-3,3-Dimethylbutanoyl]-6,6-Dimethyl-3-Azabicyclo[3.1.0]hexane-2-
Carboxamide

1
There is 1 target protein defined in DrugBank for this drug.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: B0B3C9 (B0B3C9_9HEPC)  -  Hepatitis C virus NS3-4A serine protease
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:  

 

Other proteins with boceprevir bound in the PDB

There is 1 "non-target" protein in the PDB containing the boceprevir molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P27958 ()  -  Genome polyprotein OS=Hepatitis C virus genotype 1a (isolate H) PE=1 SV=3
UniProt id: P27958    3010 a.a.  
2oc8 A   183 a.a. 179   X-ray 2.66 Å
The PDB contains 1 entry of boceprevir bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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