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DB08814 : triflusal

Approved drug triflusal ... 4 targets DB08814

Generic name: triflusal
No image
 
Brand name(s): none.
Formula: None
IUPAC Formula: None

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
UniProt id: P23219    599 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P19838 (NFKB1_HUMAN)  -  Nuclear factor NF-kappa-B p105 subunit
UniProt id: P19838    967 a.a.  
1. 1svc P     311 a.a. 310   X-ray 2.60 Å
  2. 3gut B,D,F,H     312 a.a. 306   X-ray 3.59 Å
  3. 1nfi B,D     107 a.a. 107   X-ray 2.70 Å
  4. 2dbf A     100 a.a. 88   NMR  
  5. 1mdi B     13 a.a. 13   NMR  
   more ...
There are no PDB entries containing triflusal bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P35228 (NOS2_HUMAN)  -  Nitric oxide synthase, inducible
UniProt id: P35228    1152 a.a.  
1. 3e7g A,B,C,D     421 a.a. 421   X-ray 2.20 Å
  2. 4nos A,B,C,D     421 a.a. 420   X-ray 2.25 Å
  3. 1nsi A,B,C,D     420 a.a. 420   X-ray 2.55 Å
  4. 2nsi A,B,C,D     420 a.a. 420   X-ray 3.00 Å
  5. 3ej8 A,B,C,D     421 a.a. 419   X-ray 2.55 Å
   more ...
There are no PDB entries containing triflusal bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q9Y233 (PDE10_HUMAN)  -  CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
UniProt id: Q9Y233    778 a.a.  
1. 4lm1 A,B     332 a.a. 329   X-ray 1.60 Å
  2. 4lm3 A,B     331 a.a. 328   X-ray 1.49 Å
  3. 4lm4 A,B     330 a.a. 327   X-ray 1.48 Å
  4. 4llk A,B     330 a.a. 327   X-ray 1.55 Å
  5. 4lm2 A,B     330 a.a. 327   X-ray 1.55 Å
   more ...
There are no PDB entries containing triflusal bound to this target protein, although there are 54 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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