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DB08795 : azidocillin

Approved drug azidocillin ... 5 targets DB08795

Generic name: azidocillin
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Brand name(s): none.
Formula: C16H17N5O4S
IUPAC Formula: (2s,5r,6r)-6-[(2r)-2-Azido-2-Phenylacetamido]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]heptane-
2-Carboxylic acid

5
There are 5 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q8DNB6 (Q8DNB6_STRR6)  -  Penicillin-binding protein 2a
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: Q7CRA4 (Q7CRA4_STRR6)  -  Penicillin-binding protein 1b
UniProt id: Q7CRA4    820 a.a.  
1. 2y2m A     471 a.a. 457   X-ray 1.62 Å
  2. 2y2o A     471 a.a. 457   X-ray 1.88 Å
  3. 2y2j A     470 a.a. 456   X-ray 2.06 Å
  4. 2xd5 A,B     469 a.a. 456   X-ray 2.50 Å
  5. 2y2k A     469 a.a. 455   X-ray 2.09 Å
   more ...
There are no PDB entries containing azidocillin bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q75Y35 (Q75Y35_STREE)  -  Penicillin-binding protein 3
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q8DR59 (PBPA_STRR6)  -  Penicillin-binding protein 1A
UniProt id: Q8DR59    718 a.a.  
1. 2c5w A     16 a.a. 16   X-ray 2.55 Å
  2. 2c6w A     16 a.a. 16   X-ray 2.61 Å
There are no PDB entries containing azidocillin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P0A3M6 (PBP2_STRR6)  -  Penicillin-binding protein 2B
UniProt id: P0A3M6    679 a.a.  
2waf A     619 a.a. 617   X-ray 3.29 Å
There are no PDB entries containing azidocillin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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