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DB06692 : aprotinin

Approved biotech drug aprotinin ... 4 targets DB06692

Generic name: aprotinin
No image
 
Brand name(s): trasylol.
Formula: C284H432N84O79S7
IUPAC Formula: None

4
There are 4 target proteins defined in DrugBank for this biotech drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank biotech drug Target 1:   UniProt id: P07477 (TRY1_HUMAN)  -  Trypsin-1
UniProt id: P07477    246 a.a.  
1. 2ra3 A,B     224 a.a. 222   X-ray 1.46 Å
  2. 1trn A,B     223 a.a. 222   X-ray 2.20 Å
  3. 1fxy A     228 a.a. 159   X-ray 2.15 Å
There are no PDB entries containing aprotinin bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: P17538 (CTRB1_HUMAN)  -  Chymotrypsinogen B
UniProt id: P17538    263 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank biotech drug Target 3:   UniProt id: P00747 (PLMN_HUMAN)  -  Plasminogen
UniProt id: P00747    809 a.a.  
1. 4a5t S     767 a.a. 767   X-ray 3.49 Å
  2. 4dur A,B     756 a.a. 756   X-ray 2.45 Å
  3. 4duu A     682 a.a. 682   X-ray 5.20 Å
  4. 1ki0 A     253 a.a. 252   X-ray 1.75 Å
  5. 1bml A,B     250 a.a. 249   X-ray 2.90 Å
   more ...
There are no PDB entries containing aprotinin bound to this target protein, although there are 30 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 4:   UniProt id: P06870 (KLK1_HUMAN)  -  Kallikrein-1
UniProt id: P06870    261 a.a.  
1spj A     236 a.a. 236   X-ray 1.70 Å
There are no PDB entries containing aprotinin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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