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DB06637 : dalfampridine

Approved drug dalfampridine ... 16 targets DB06637

Generic name: dalfampridine PDB Het Group: 4AP
 
2 structures in PDB
Brand name(s): ampyra, fampyra.
Formula: C5H6N2
IUPAC Formula: Pyridin-4-Amine
PDB name: 4-Aminopyridine

16
There are 16 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q92953 (KCNB2_HUMAN)  -  Potassium voltage-gated channel subfamily B member 2
UniProt id: Q92953    911 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P48547 (KCNC1_HUMAN)  -  Potassium voltage-gated channel subfamily C member 1
UniProt id: P48547    511 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q96PR1 (KCNC2_HUMAN)  -  Potassium voltage-gated channel subfamily C member 2
UniProt id: Q96PR1    638 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q14003 (KCNC3_HUMAN)  -  Potassium voltage-gated channel subfamily C member 3
UniProt id: Q14003    757 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q9NSA2 (KCND1_HUMAN)  -  Potassium voltage-gated channel subfamily D member 1
UniProt id: Q9NSA2    647 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: Q9NZV8 (KCND2_HUMAN)  -  Potassium voltage-gated channel subfamily D member 2
UniProt id: Q9NZV8    630 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: Q9UK17 (KCND3_HUMAN)  -  Potassium voltage-gated channel subfamily D member 3
UniProt id: Q9UK17    654 a.a.  
1. 2nz0 B,D     136 a.a. 136   X-ray 3.20 Å
  2. 1s1g A,B     107 a.a. 106   X-ray 2.60 Å
There are no PDB entries containing dalfampridine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: Q09470 (KCNA1_HUMAN)  -  Potassium voltage-gated channel subfamily A member 1
UniProt id: Q09470    494 a.a.  
2afl A,B,C,D     82 a.a. 82   Theor. model
There are no PDB entries containing dalfampridine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 9:   UniProt id: P16389 (KCNA2_HUMAN)  -  Potassium voltage-gated channel subfamily A member 2
UniProt id: P16389    499 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: P22001 (KCNA3_HUMAN)  -  Potassium voltage-gated channel subfamily A member 3
UniProt id: P22001    574 a.a.  
4bgc A     101 a.a. 99   X-ray 1.20 Å
There are no PDB entries containing dalfampridine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 11:   UniProt id: P22459 (KCNA4_HUMAN)  -  Potassium voltage-gated channel subfamily A member 4
UniProt id: P22459    653 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 12:   UniProt id: P22460 (KCNA5_HUMAN)  -  Potassium voltage-gated channel subfamily A member 5
UniProt id: P22460    613 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: P17658 (KCNA6_HUMAN)  -  Potassium voltage-gated channel subfamily A member 6
UniProt id: P17658    529 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 14:   UniProt id: Q96RP8 (KCNA7_HUMAN)  -  Potassium voltage-gated channel subfamily A member 7
UniProt id: Q96RP8    456 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 15:   UniProt id: Q16322 (KCA10_HUMAN)  -  Potassium voltage-gated channel subfamily A member 10
UniProt id: Q16322    511 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 16:   UniProt id: Q14721 (KCNB1_HUMAN)  -  Potassium voltage-gated channel subfamily B member 1
UniProt id: Q14721    858 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with dalfampridine bound in the PDB

There are 2 "non-target" proteins in the PDB containing the dalfampridine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P00431 ()  -  Cytochrome c peroxidase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCP1 PE=1 SV=2
UniProt id: P00431    360 a.a.  
1aeg A   291 a.a. 287   X-ray 2.10 Å
The PDB contains 1 entry of dalfampridine bound to this protein
Protein 2:   UniProt id: P00760 ()  -  Cationic trypsin OS=Bos taurus PE=1 SV=3
UniProt id: P00760    245 a.a.  
3rxf A   223 a.a. 223   X-ray 1.70 Å
The PDB contains 1 entry of dalfampridine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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