spacer
spacer

Search 

DB05271 : rotigotine

Approved drug rotigotine ... 7 targets DB05271

Generic name: rotigotine
 
Brand name(s): neupro.
Formula: C19H25Nos
IUPAC Formula: 6-{Propyl[2-(Thiophen-2-Yl)ethyl]amino}-5,6,7,8-Tetrahydronaphthalen-1-Ol

7
There are 7 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P35462 (DRD3_HUMAN)  -  D(3) dopamine receptor
UniProt id: P35462    400 a.a.  
   more ...
There are no PDB entries containing rotigotine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P21917 (DRD4_HUMAN)  -  D(4) dopamine receptor
UniProt id: P21917    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing rotigotine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P21918 (DRD5_HUMAN)  -  D(1B) dopamine receptor
UniProt id: P21918    477 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing rotigotine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 6:   UniProt id: P08908 (5HT1A_HUMAN)  -  5-hydroxytryptamine 1A receptor
UniProt id: P08908    422 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing rotigotine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer