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DB05266 : ibudilast

Approved drug ibudilast ... 5 targets DB05266

Generic name: ibudilast PDB Het Group: AVL
 
1 structure in PDB
Brand name(s): none.
Formula: C14H18N2O
IUPAC Formula: 2-Methyl-1-[2-(Propan-2-Yl)pyrazolo[1,5-A]pyridin-3-Yl]propan-1-One
PDB name: 2-Methyl-1-[2-(Propan-2-Yl)pyrazolo[1,5-A]pyridin-3-Yl]propan-1-One

5
There are 5 target proteins defined in DrugBank for this drug.
 5 
5 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P27815 (PDE4A_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4A
UniProt id: P27815    885 a.a.  
1. 2qyk A,B     334 a.a. 333   X-ray 2.10 Å
  2. 3tvx A,B     334 a.a. 333   X-ray 2.84 Å
  3. 3i8v A,B     334 a.a. 331   X-ray 2.25 Å
There are no PDB entries containing ibudilast bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q07343 (PDE4B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt id: Q07343    735 a.a.  
1. 3g45 A,B     371 a.a. 371   X-ray 2.63 Å
  2. 3hmv A,B     351 a.a. 350   X-ray 2.23 Å
  3. 1f0j A,B     351 a.a. 349   X-ray 1.77 Å
  4. 1jp1 A     351 a.a. 349   Theor. model
  5. 1jp2 A     351 a.a. 349   Theor. model
   more ...
There are no PDB entries containing ibudilast bound to this target protein, although there are 36 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q08493 (PDE4C_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4C
UniProt id: Q08493    711 a.a.  
1. 1lxu A     344 a.a. 344   Theor. model
  2. 2qym A     291 a.a. 291   X-ray 1.90 Å
There are no PDB entries containing ibudilast bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q08499 (PDE4D_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4D
UniProt id: Q08499    808 a.a.  
1. 3g58 A,B,C,D     335 a.a. 335   X-ray 2.05 Å
  2. 1oyn A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  3. 2fm0 A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  4. 2fm5 A,B,C,D     334 a.a. 334   X-ray 2.03 Å
  5. 1rko A,B,C,D     334 a.a. 334   X-ray 2.10 Å
   more ...
There are no PDB entries containing ibudilast bound to this target protein, although there are 37 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: Q14432 (PDE3A_HUMAN)  -  CGMP-inhibited 3',5'-cyclic phosphodiesterase A
UniProt id: Q14432    1140 a.a.  
1lrc A     206 a.a. 206   Theor. model
There are no PDB entries containing ibudilast bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with ibudilast bound in the PDB

There is 1 "non-target" protein in the PDB containing the ibudilast molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P14174 ()  -  Macrophage migration inhibitory factor OS=Homo sapiens GN=MIF PE=1 SV=4
UniProt id: P14174    115 a.a.  
4grq A,B,C   116 a.a. 113   X-ray 1.65 Å
The PDB contains 1 entry of ibudilast bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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