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DB04967 : lucanthone

Approved drug lucanthone ... 4 targets DB04967

Generic name: lucanthone
 
Brand name(s): miracil d, miracol, nilodin, scapuren, tixantone.
Formula: C20H24N2Os
IUPAC Formula: 1-{[2-(Diethylamino)ethyl]amino}-4-Methyl-9h-Thioxanthen-9-One

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P11388 (TOP2A_HUMAN)  -  DNA topoisomerase 2-alpha
UniProt id: P11388    1530 a.a.  
1. 1lwz A     779 a.a. 771   Theor. model
  2. 4fm9 A     727 a.a. 727   X-ray 2.90 Å
  3. 1zxm A,B     373 a.a. 373   X-ray 1.87 Å
  4. 1zxn A,B,C,D     366 a.a. 366   X-ray 2.51 Å
There are no PDB entries containing lucanthone bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P27695 (APEX1_HUMAN)  -  DNA-(apurinic or apyrimidinic site) lyase
UniProt id: P27695    317 a.a.  
1. 4iem A,B,C,D     278 a.a. 278   X-ray 2.39 Å
  2. 2o3h A     280 a.a. 277   X-ray 1.90 Å
  3. 1dew A,B     278 a.a. 277   X-ray 2.65 Å
  4. 2isi A,B,C     276 a.a. 276   X-ray 2.76 Å
  5. 4lnd A,B,C     275 a.a. 275   X-ray 1.92 Å
   more ...
There are no PDB entries containing lucanthone bound to this target protein, although there are 13 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P11387 (TOP1_HUMAN)  -  DNA topoisomerase 1
UniProt id: P11387    764 a.a.  
1. 1sc7 A     566 a.a. 565   X-ray 3.00 Å
  2. 1k4t A     564 a.a. 563   X-ray 2.10 Å
  3. 1t8i A     564 a.a. 563   X-ray 3.00 Å
  4. 1tl8 A     564 a.a. 563   X-ray 3.10 Å
  5. 1rrj A     564 a.a. 562   X-ray 2.30 Å
   more ...
There are no PDB entries containing lucanthone bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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