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DB04946 : iloperidone

Approved drug iloperidone ... 11 targets DB04946

Generic name: iloperidone
 
Brand name(s): fanapt, fiapta, zomaril.
Formula: C24H27Fn2O4
IUPAC Formula: 1-(4-{3-[4-(6-Fluoro-1,2-Benzoxazol-3-Yl)piperidin-1-Yl]propoxy}-3-Methoxyphenyl)ethan-1-One

11
There are 11 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing iloperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P18825 (ADA2C_HUMAN)  -  Alpha-2C adrenergic receptor
UniProt id: P18825    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing iloperidone bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing iloperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 6:   UniProt id: P35462 (DRD3_HUMAN)  -  D(3) dopamine receptor
UniProt id: P35462    400 a.a.  
   more ...
There are no PDB entries containing iloperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: P21917 (DRD4_HUMAN)  -  D(4) dopamine receptor
UniProt id: P21917    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P08908 (5HT1A_HUMAN)  -  5-hydroxytryptamine 1A receptor
UniProt id: P08908    422 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: P50406 (5HT6R_HUMAN)  -  5-hydroxytryptamine 6 receptor
UniProt id: P50406    440 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: P34969 (5HT7R_HUMAN)  -  5-hydroxytryptamine 7 receptor
UniProt id: P34969    479 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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