spacer
spacer

Search 

DB04942 : tamibarotene

Approved drug tamibarotene ... 2 targets DB04942

Generic name: tamibarotene PDB Het Group: A80
 
1 structure in PDB
Brand name(s): amnoid, tamibaro.
Formula: C22H25No3
IUPAC Formula: 4-[(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)carbamoyl]benzoic acid
PDB name: 4-[(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)carbamoyl]benzoic acid

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
ChEBI
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P10276 (RARA_HUMAN)  -  Retinoic acid receptor alpha
UniProt id: P10276    461 a.a.  
1. 3a9e B     239 a.a. 239   X-ray 2.75 Å
  2. 3kmr A     234 a.a. 234   X-ray 1.80 Å
  3. 4dqm A,C     234 a.a. 234   X-ray 2.75 Å
  4. 1dkf B     232 a.a. 232   X-ray 2.50 Å
  5. 3kmz B,A     221 a.a. 221   X-ray 2.10 Å
There are no PDB entries containing tamibarotene bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P10826 (RARB_HUMAN)  -  Retinoic acid receptor beta
UniProt id: P10826    454 a.a.  
1. 4dm6 A,B     240 a.a. 240   X-ray 1.90 Å
  2. 4jyi A,B     239 a.a. 238   X-ray 1.90 Å
  3. 4dm8 A,B     238 a.a. 238   X-ray 2.30 Å
  4. 4jyg A,B     239 a.a. 238   X-ray 2.35 Å
  5. 4jyh A,B     239 a.a. 238   X-ray 2.60 Å
   more ...
There are no PDB entries containing tamibarotene bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with tamibarotene bound in the PDB

There is 1 "non-target" protein in the PDB containing the tamibarotene molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P62964 ()  -  Cellular retinoic acid-binding protein 1 OS=Bos taurus GN=CRABP1 PE=1 SV=2
UniProt id: P62964    136 a.a.  
2cbr A   136 a.a. 136   X-ray 2.80 Å
The PDB contains 1 entry of tamibarotene bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer