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DB04896 : milnacipran

Approved drug milnacipran ... 3 targets DB04896

Generic name: milnacipran
 
Brand name(s): dalcipran, ixel, savella, toledomin.
Formula: C15H22N2O
IUPAC Formula: (1r,2s)-2-(Aminomethyl)-N,N-Diethyl-1-Phenylcyclopropane-1-Carboxamide

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P31645 (SC6A4_HUMAN)  -  Sodium-dependent serotonin transporter
UniProt id: P31645    630 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P23975 (SC6A2_HUMAN)  -  Sodium-dependent noradrenaline transporter
UniProt id: P23975    617 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q05586 (NMDZ1_HUMAN)  -  Glutamate [NMDA] receptor subunit zeta-1
UniProt id: Q05586    937 a.a.  
1. 2nr1 A     23 a.a. 23   NMR  
  2. 2hqw B     22 a.a. 22   X-ray 1.90 Å
  3. 3bya B     20 a.a. 20   X-ray 1.85 Å
There are no PDB entries containing milnacipran bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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