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DB04896 : milnacipran

Approved drug milnacipran ... 3 targets DB04896

Generic name: milnacipran
 
Brand name(s): dalcipran, ixel, savella, toledomin.
Formula: C15H22N2O
IUPAC Formula: (1r,2s)-2-(Aminomethyl)-N,N-Diethyl-1-Phenylcyclopropane-1-Carboxamide

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P31645 (SC6A4_HUMAN)  -  Sodium-dependent serotonin transporter
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P23975 (SC6A2_HUMAN)  -  Sodium-dependent noradrenaline transporter
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q05586 (NMDZ1_HUMAN)  -  Glutamate [NMDA] receptor subunit zeta-1
UniProt id: Q05586    937 a.a.  
1. 2nr1 A     23 a.a. 23   NMR  
  2. 2hqw B     22 a.a. 22   X-ray 1.90 Å
  3. 3bya B     20 a.a. 20   X-ray 1.85 Å
There are no PDB entries containing milnacipran bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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