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DB04855 : dronedarone

Approved drug dronedarone ... 18 targets DB04855

Generic name: dronedarone
 
Brand name(s): multaq.
Formula: C31H44N2O5S
IUPAC Formula: N-[2-Butyl-3-({4-[3-(Dibutylamino)propoxy]phenyl}carbonyl)-1-Benzofuran-5-Yl]methanesulfonamide

18
There are 18 target proteins defined in DrugBank for this drug.
 8 
8 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q01668 (CAC1D_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt id: Q01668    2161 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: O60840 (CAC1F_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1F
UniProt id: O60840    1977 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q13698 (CAC1S_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt id: Q13698    1872 a.a.  
2vay B     21 a.a. 21   X-ray 1.94 Å
There are no PDB entries containing dronedarone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 4:   UniProt id: Q02641 (CACB1_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-1
UniProt id: Q02641    598 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q08289 (CACB2_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-2
UniProt id: Q08289    660 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P54284 (CACB3_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-3
UniProt id: P54284    484 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: O00305 (CACB4_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-4
UniProt id: O00305    519 a.a.  
2d46 A     61 a.a. 44   NMR  
There are no PDB entries containing dronedarone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 8:   UniProt id: P35498 (SCN1A_HUMAN)  -  Sodium channel protein type 1 subunit alpha
UniProt id: P35498    2009 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: O95069 (KCNK2_HUMAN)  -  Potassium channel subfamily K member 2
UniProt id: O95069    425 a.a.  
4twk A     255 a.a. 249   X-ray 2.60 Å
There are no PDB entries containing dronedarone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 10:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 12:   UniProt id: P25100 (ADA1D_HUMAN)  -  Alpha-1D adrenergic receptor
UniProt id: P25100    572 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing dronedarone bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 14:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing dronedarone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 15:   UniProt id: P18825 (ADA2C_HUMAN)  -  Alpha-2C adrenergic receptor
UniProt id: P18825    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 16:   UniProt id: P08588 (ADRB1_HUMAN)  -  Beta-1 adrenergic receptor
UniProt id: P08588    476 a.a.  
2lsq A     25 a.a. 19   NMR  
There are no PDB entries containing dronedarone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 17:   UniProt id: Q12809 (KCNH2_HUMAN)  -  Potassium voltage-gated channel subfamily H member 2
UniProt id: Q12809    1158 a.a.  
1. 2l0w A     135 a.a. 134   NMR  
  2. 2l1m A     135 a.a. 134   NMR  
  3. 2l4r A     135 a.a. 134   NMR  
  4. 4hp9 A     119 a.a. 119   X-ray 2.12 Å
  5. 4hqa A     110 a.a. 110   X-ray 1.96 Å
   more ...
There are no PDB entries containing dronedarone bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 18:   UniProt id: Q13936 (CAC1C_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt id: Q13936    2220 a.a.  
1. 3g43 E     68 a.a. 66   X-ray 2.10 Å
  2. 3oxq E,F     64 a.a. 63   X-ray 2.55 Å
  3. 2be6 D     29 a.a. 29   X-ray 2.00 Å
  4. 2lqc B     24 a.a. 22   NMR  
  5. 2f3z B     18 a.a. 16   X-ray 1.60 Å
There are no PDB entries containing dronedarone bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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