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DB04842 : fluspirilene

Approved drug fluspirilene ... 3 targets DB04842

Generic name: fluspirilene
 
Brand name(s): imap, lopac-f-100, redeptin.
Formula: C29H31F2N3O
IUPAC Formula: 8-[4,4-Bis(4-Fluorophenyl)butyl]-1-Phenyl-1,3,8-Triazaspiro[4.5]decan-4-One

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing fluspirilene bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q06432 (CCG1_HUMAN)  -  Voltage-dependent calcium channel gamma-1 subunit
UniProt id: Q06432    222 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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