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DB04841 : flunarizine

Approved drug flunarizine ... 5 targets DB04841

Generic name: flunarizine
 
Brand name(s): apo-flunarizine capsules, flufenal, fluvert, issium, novo-flunarizine, sibelium, vertix, zinasen.
Formula: C26H26F2N2
IUPAC Formula: 1-[Bis(4-Fluorophenyl)methyl]-4-[(2e)-3-Phenylprop-2-En-1-Yl]piperazine

5
There are 5 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: O43497 (CAC1G_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1G
UniProt id: O43497    2377 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: O95180 (CAC1H_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1H
UniProt id: O95180    2353 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q9P0X4 (CAC1I_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1I
UniProt id: Q9P0X4    2223 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing flunarizine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1. 4djc A     151 a.a. 148   X-ray 1.35 Å
  2. 2jzi A     148 a.a. 148   NMR  
  3. 2k0e A     148 a.a. 148   NMR  
  4. 2kne A     148 a.a. 148   NMR  
  5. 2l53 A     148 a.a. 148   NMR  
   more ...
There are no PDB entries containing flunarizine bound to this target protein, although there are 90 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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