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DB04570 : latamoxef

Approved drug latamoxef ... 4 targets DB04570

Generic name: latamoxef
 
Brand name(s): none.
Formula: C20H20N6O9S
IUPAC Formula: (6r,7r)-7-[2-Carboxy-2-(4-Hydroxyphenyl)acetamido]-7-Methoxy-3-{[(1-Methyl-1h-1,2,3,4-Tetrazol-5-
Yl)sulfanyl]methyl}-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylic acid

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
Links  
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ChEBI
KEGG drug
PubChem
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Target proteins

DrugBank drug Target 1:   UniProt id: P42971 (PBPC_BACSU)  -  Penicillin-binding protein 3
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P02918 (PBPA_ECOLI)  -  Penicillin-binding protein 1A
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P02919 (PBPB_ECOLI)  -  Penicillin-binding protein 1B
UniProt id: P02919    843 a.a.  
1. 3vma A     708 a.a. 708   X-ray 2.16 Å
  2. 3fwl A     707 a.a. 707   X-ray 3.09 Å
  3. 3fwm A     666 a.a. 666   X-ray 2.16 Å
There are no PDB entries containing latamoxef bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P24228 (DACB_ECOLI)  -  Penicillin-binding protein 4
UniProt id: P24228    476 a.a.  
1. 2ex2 A     456 a.a. 455   X-ray 1.55 Å
  2. 2ex8 A     456 a.a. 455   X-ray 1.60 Å
  3. 2ex6 A     450 a.a. 449   X-ray 1.60 Å
  4. 2exb A     446 a.a. 445   X-ray 1.75 Å
  5. 2exa A     443 a.a. 442   X-ray 1.70 Å
There are no PDB entries containing latamoxef bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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