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DB04552 : niflumic acid

Approved drug niflumic acid ... 6 targets DB04552

Generic name: niflumic acid PDB Het Group: NFL
 
2 structures in PDB
Brand name(s): actol, flogovital, forenol, landruma, niflam, nifluril.
Formula: C13H9F3N2O2
IUPAC Formula: 2-{[3-(Trifluoromethyl)phenyl]amino}pyridine-3-Carboxylic acid
PDB name: 2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid

6
There are 6 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P04054 (PA21B_HUMAN)  -  Phospholipase A2
UniProt id: P04054    147 a.a.  
1. 3elo A     133 a.a. 133   X-ray 1.55 Å
  2. 1ysk A     124 a.a. 124   Theor. model
There are no PDB entries containing niflumic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing niflumic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P51800 (CLCKA_HUMAN)  -  Chloride channel protein ClC-Ka
UniProt id: P51800    686 a.a.  
2pfi A,B     145 a.a. 139   X-ray 1.60 Å
There are no PDB entries containing niflumic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 4:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P47712 (PA24A_HUMAN)  -  Cytosolic phospholipase A2
UniProt id: P47712    748 a.a.  
1. 1cjy A,B     633 a.a. 632   X-ray 2.50 Å
  2. 1rlw A     126 a.a. 123   X-ray 2.40 Å
  3. 1bci A     123 a.a. 123   NMR  
There are no PDB entries containing niflumic acid bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: O60656 (UD19_HUMAN)  -  UDP-glucuronosyltransferase 1-9
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with niflumic acid bound in the PDB

There are 2 "non-target" proteins in the PDB containing the niflumic acid molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P60045 ()  -  Acidic phospholipase A2 3 (Fragment) OS=Naja sagittifera PE=1 SV=1
UniProt id: P60045    125 a.a.  
1td7 A   119 a.a. 119   X-ray 2.50 Å
The PDB contains 1 entry of niflumic acid bound to this protein
Protein 2:   UniProt id: Q9HBL8 ()  -  NmrA-like family domain-containing protein 1 OS=Homo sapiens GN=NMRAL1 PE=1 SV=1
UniProt id: Q9HBL8    298 a.a.  
2wm3 A   296 a.a. 296   X-ray 1.85 Å
The PDB contains 1 entry of niflumic acid bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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