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DB02703 : fusidic acid

Approved drug fusidic acid ... 3 targets DB02703

Generic name: fusidic acid PDB Het Group: FUA
 
14 structures in PDB
Brand name(s): fucidin, fucidin cream 2%, fucidin acid, fucidine, fucithalmic, fusidine, ramycin.
Formula: C31H48O6
IUPAC Formula: 2-[(1s,2s,5r,6s,7s,10s,11s,13s,14z,15r,17r)-13-(Acetyloxy)-5,17-Dihydroxy-2,6,10,11-
Tetramethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-Ylidene]-6-Methylhept-5-Enoic acid
PDB name: Fusidic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Information  
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Target proteins

DrugBank drug Target 1:   UniProt id: P13551 (EFG_THETH)  -  Elongation factor G
UniProt id: P13551    690 a.a.  
1. 1jqm   B     691 a.a. 689   Not given  
  2. 3izp E     688 a.a. 686   Not given  
  3. 2bm0 A     666 a.a. 664   X-ray 2.40 Å
  4. 2bm1 A     660 a.a. 659   X-ray 2.60 Å
  5. 2j7k A     660 a.a. 659   X-ray 2.90 Å
   more ...
There are no PDB entries containing fusidic acid bound to this target protein, although there are 18 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P62580 (CAT_SALTI)  -  Chloramphenicol acetyltransferase
UniProt id: P62580    219 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P00484 (CAT3_ECOLX)  -  Chloramphenicol acetyltransferase 3
UniProt id: P00484    212 a.a.  
1qca A   211 a.a. 206   X-ray 2.20 Å
The PDB contains 1 entry of fusidic acid bound to this target protein and 6 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with fusidic acid bound in the PDB

There are 2 "non-target" proteins in the PDB containing the fusidic acid molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P02768 ()  -  Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2
UniProt id: P02768    608 a.a.  
2vuf A,B   556 a.a. 556   X-ray 3.05 Å
The PDB contains 1 entry of fusidic acid bound to this protein
Protein 2:   UniProt id: P62577 ()  -  Chloramphenicol acetyltransferase OS=Escherichia coli GN=cat PE=1 SV=1
UniProt id: P62577    218 a.a.  
1q23 A,B,C,D,...   214 a.a. 214   X-ray 2.18 Å
The PDB contains 1 entry of fusidic acid bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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