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DB01764 : dalfopristin

Approved drug dalfopristin ... 1 target DB01764

Generic name: dalfopristin PDB Het Group: DOL
 
7 structures in PDB
Brand name(s): none.
Formula: C34H50N4O9S
IUPAC Formula: (6r,10r,11r,21s)-6-{[2-(Diethylamino)ethane]sulfonyl}-21-Hydroxy-11,19-Dimethyl-10-(Propan-2-Yl)-
9,26-Dioxa-3,15,28-Triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),12,17,19,25(28)-Pentaene-2,8,14,23-
Tetrone
PDB name: 5-(2-Diethylamino-Ethanesulfonyl)-21-Hydroxy-10-Isopropyl-11,19-Dimethyl-9,26-Dioxa-3,15,28-Triaza-
Tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-Pentaene-2,8,14,23-Tetraone

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P50870 (VATD_ENTFC)  -  Streptogramin A acetyltransferase
UniProt id: P50870    208 a.a.  
1mrl A,B,C   204 a.a. 203   X-ray 2.80 Å
The PDB contains 1 entry of dalfopristin bound to this target protein and 8 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with dalfopristin bound in the PDB

There is 1 "non-target" protein in the PDB containing the dalfopristin molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P17978 ()  -  Virginiamycin B lyase OS=Staphylococcus aureus GN=vgb PE=1 SV=1
UniProt id: P17978    298 a.a.  
2z2p A,B   293 a.a. 285   X-ray 2.80 Å
The PDB contains 1 entry of dalfopristin bound to this protein

Key:    PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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