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DB01626 : pargyline

Approved drug pargyline ... 2 targets DB01626

Generic name: pargyline
 
Brand name(s): eudatin, eutonyl, eutonyl-ten, lopac-p-8013, supirdyl.
Formula: C11H13N
IUPAC Formula: Benzyl(methyl)(prop-2-Yn-1-Yl)amine

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P27338 (AOFB_HUMAN)  -  Amine oxidase [flavin-containing] B
UniProt id: P27338    519 a.a.  
1. 1s3e A,B     499 a.a. 499   X-ray 1.60 Å
  2. 2v5z A,B     499 a.a. 499   X-ray 1.60 Å
  3. 2xfn A,B     499 a.a. 499   X-ray 1.60 Å
  4. 1s3b A,B     499 a.a. 499   X-ray 1.65 Å
  5. 2xfp A,B     499 a.a. 499   X-ray 1.66 Å
   more ...
There are no PDB entries containing pargyline bound to this target protein, although there are 41 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P21397 (AOFA_HUMAN)  -  Amine oxidase [flavin-containing] A
UniProt id: P21397    526 a.a.  
1. 2z5x A     513 a.a. 513   X-ray 2.20 Å
  2. 2z5y A     513 a.a. 512   X-ray 2.17 Å
  3. 2bxs A,B     490 a.a. 490   X-ray 3.15 Å
  4. 1h8q A     455 a.a. 455   Theor. model
  5. 2bxr A,B     445 a.a. 445   X-ray 3.00 Å
There are no PDB entries containing pargyline bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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