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DB01576 : dextroamphetamine

Approved drug dextroamphetamine ... 6 targets DB01576

Generic name: dextroamphetamine PDB Het Group: 1WE
 
1 structure in PDB
Brand name(s): amsustain, dephadren, dexacaps, dexadrine, dexedrine, dexidrine, dextrostat.
Formula: C9H13N
IUPAC Formula: (2s)-1-Phenylpropan-2-Amine
PDB name: (2s)-1-Phenylpropan-2-Amine

6
There are 6 target proteins defined in DrugBank for this drug.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q05940 (VMAT2_HUMAN)  -  Synaptic vesicular amine transporter
UniProt id: Q05940    514 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P23975 (SC6A2_HUMAN)  -  Sodium-dependent noradrenaline transporter
UniProt id: P23975    617 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q01959 (SC6A3_HUMAN)  -  Sodium-dependent dopamine transporter
UniProt id: Q01959    620 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q96RJ0 (TAAR1_HUMAN)  -  Trace amine-associated receptor 1
UniProt id: Q96RJ0    339 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain

 

Other proteins with dextroamphetamine bound in the PDB

There is 1 "non-target" protein in the PDB containing the dextroamphetamine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   Crystal structures of a therapeutic single chain antibody in form and in complex with amphetamine and 4-hydroxymethamphe
  No Pfam domain assignments available for this protein.
1. 4lar H   117 a.a. 117   X-ray 2.38 Å
  2.    " L   115 a.a. 30   "

Key:    Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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