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DB01452 : heroin

Approved drug heroin ... 3 targets DB01452

Generic name: heroin
 
Brand name(s): none.
Formula: C21H23No5
IUPAC Formula: (1s,5r,13r,14s,17r)-10-(Acetyloxy)-4-Methyl-12-Oxa-4-
Azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-Tetraen-14-Yl acetate

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35372 (OPRM_HUMAN)  -  Mu-type opioid receptor
UniProt id: P35372    400 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P41145 (OPRK_HUMAN)  -  Kappa-type opioid receptor
UniProt id: P41145    379 a.a.  
2a0d A     380 a.a. 378   Theor. model
There are no PDB entries containing heroin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P41143 (OPRD_HUMAN)  -  Delta-type opioid receptor
UniProt id: P41143    371 a.a.  
1ozc A     268 a.a. 268   Theor. model
There are no PDB entries containing heroin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

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