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DB01427 : amrinone

Approved drug amrinone ... 3 targets DB01427

Generic name: amrinone
 
Brand name(s): amcoral, cartonic, cordarex, cordemcura, inocor, wincoram.
Formula: C10H9N3O
IUPAC Formula: 3-Amino-5-(Pyridin-4-Yl)-1,2-Dihydropyridin-2-One

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14432 (PDE3A_HUMAN)  -  CGMP-inhibited 3',5'-cyclic phosphodiesterase A
UniProt id: Q14432    1140 a.a.  
1lrc A     206 a.a. 206   Theor. model
There are no PDB entries containing amrinone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: Q07343 (PDE4B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt id: Q07343    735 a.a.  
1. 3g45 A,B     371 a.a. 371   X-ray 2.63 Å
  2. 3hmv A,B     351 a.a. 350   X-ray 2.23 Å
  3. 1f0j A,B     351 a.a. 349   X-ray 1.77 Å
  4. 1jp1 A     351 a.a. 349   Theor. model
  5. 1jp2 A     351 a.a. 349   Theor. model
   more ...
There are no PDB entries containing amrinone bound to this target protein, although there are 36 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P01375 (TNFA_HUMAN)  -  Tumor necrosis factor
UniProt id: P01375    232 a.a.  
1. 1a8m A,B,C     152 a.a. 151   X-ray 2.30 Å
  2. 1tnf A,B,C     152 a.a. 151   X-ray 2.60 Å
  3. 3it8 A,B,C,G,...     152 a.a. 151   X-ray 2.80 Å
  4. 3wd5 A     152 a.a. 151   X-ray 3.10 Å
  5. 3l9j T     149 a.a. 149   X-ray 2.10 Å
   more ...
There are no PDB entries containing amrinone bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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