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DB01411 : pranlukast

Approved drug pranlukast ... 6 targets DB01411

Generic name: pranlukast
 
Brand name(s): none.
Formula: C27H23N5O4
IUPAC Formula: N-[4-Oxo-2-(2h-1,2,3,4-Tetrazol-5-Yl)-4h-Chromen-7-Yl]-4-(4-Phenylbutoxy)benzamide

6
There are 6 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q9Y271 (CLTR1_HUMAN)  -  Cysteinyl leukotriene receptor 1
UniProt id: Q9Y271    337 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P01375 (TNFA_HUMAN)  -  Tumor necrosis factor
UniProt id: P01375    232 a.a.  
1. 1a8m A,B,C     152 a.a. 151   X-ray 2.30 Å
  2. 1tnf A,B,C     152 a.a. 151   X-ray 2.60 Å
  3. 3it8 A,B,C,G,...     152 a.a. 151   X-ray 2.80 Å
  4. 3wd5 A     152 a.a. 151   X-ray 3.10 Å
  5. 3l9j T     149 a.a. 149   X-ray 2.10 Å
   more ...
There are no PDB entries containing pranlukast bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P05113 (IL5_HUMAN)  -  Interleukin-5
UniProt id: P05113    133 a.a.  
1. 3qt2 C,D,E,F     110 a.a. 110   X-ray 2.55 Å
  2. 1hul A,B     108 a.a. 108   X-ray 2.40 Å
  3. 3va2 A,B     107 a.a. 107   X-ray 2.70 Å
There are no PDB entries containing pranlukast bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P12724 (ECP_HUMAN)  -  Eosinophil cationic protein
UniProt id: P12724    159 a.a.  
1. 4a2o A,B     133 a.a. 132   X-ray 1.69 Å
  2. 4a2y A,B     133 a.a. 132   X-ray 1.70 Å
  3. 1dyt A,B     133 a.a. 132   X-ray 1.75 Å
  4. 1h1h A     134 a.a. 132   X-ray 2.00 Å
  5. 1qmt A     134 a.a. 132   X-ray 2.40 Å
   more ...
There are no PDB entries containing pranlukast bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P19838 (NFKB1_HUMAN)  -  Nuclear factor NF-kappa-B p105 subunit
UniProt id: P19838    967 a.a.  
1. 1svc P     311 a.a. 310   X-ray 2.60 Å
  2. 3gut B,D,F,H     312 a.a. 306   X-ray 3.59 Å
  3. 1nfi B,D     107 a.a. 107   X-ray 2.70 Å
  4. 2dbf A     100 a.a. 88   NMR  
  5. 1mdi B     13 a.a. 13   NMR  
   more ...
There are no PDB entries containing pranlukast bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: Q02817 (MUC2_HUMAN)  -  Mucin-2
UniProt id: Q02817    5179 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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