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DB01406 : danazol

Approved drug danazol ... 6 targets DB01406

Generic name: danazol
 
Brand name(s): anatrol, chronogyn, cyclomen, danocrine.
Formula: C22H27No2
IUPAC Formula: (1s,2r,13r,14s,17r,18s)-17-Ethynyl-2,18-Dimethyl-7-Oxa-6-
Azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-Trien-17-Ol

6
There are 6 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
Links  
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ChEBI
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PubChem
Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P03372 (ESR1_HUMAN)  -  Estrogen receptor
UniProt id: P03372    594 a.a.  
1. 1qku A,B,C     250 a.a. 250   X-ray 3.20 Å
  2. 3ert A     247 a.a. 247   X-ray 1.90 Å
  3. 1g50 A,B,C     247 a.a. 247   X-ray 2.90 Å
  4. 2ouz A     246 a.a. 246   X-ray 2.00 Å
  5. 3erd A,B     246 a.a. 246   X-ray 2.03 Å
   more ...
There are no PDB entries containing danazol bound to this target protein, although there are 102 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P10275 (ANDR_HUMAN)  -  Androgen receptor
UniProt id: P10275    918 a.a.  
1. 1xj7 A     256 a.a. 256   X-ray 2.70 Å
  2. 1t65 A     251 a.a. 251   X-ray 1.66 Å
  3. 2am9 A     250 a.a. 250   X-ray 1.64 Å
  4. 2pit A     250 a.a. 250   X-ray 1.76 Å
  5. 1t63 A     250 a.a. 250   X-ray 2.07 Å
   more ...
There are no PDB entries containing danazol bound to this target protein, although there are 76 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P06401 (PRGR_HUMAN)  -  Progesterone receptor
UniProt id: P06401    932 a.a.  
1. 1a28 A,B     251 a.a. 251   X-ray 1.80 Å
  2. 2w8y A,B     251 a.a. 251   X-ray 1.80 Å
  3. 1zuc B,A     251 a.a. 251   X-ray 2.00 Å
  4. 1e3k A,B     251 a.a. 251   X-ray 2.80 Å
  5. 3zr7 A,B     250 a.a. 250   X-ray 1.65 Å
   more ...
There are no PDB entries containing danazol bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P30968 (GNRHR_HUMAN)  -  Gonadotropin-releasing hormone receptor
UniProt id: P30968    328 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q96P88 (GNRR2_HUMAN)  -  Gonadotropin-releasing hormone II receptor
UniProt id: Q96P88    178 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P13500 (CCL2_HUMAN)  -  Small inducible cytokine A2
UniProt id: P13500    98 a.a.  
1. 1dom A,B     76 a.a. 76   NMR  
  2. 1don A,B     76 a.a. 76   NMR  
  3. 1dok A,B     72 a.a. 71   X-ray 1.85 Å
  4. 1dol A     71 a.a. 70   X-ray 2.40 Å
  5. 2bdn A     68 a.a. 68   X-ray 2.53 Å
   more ...
There are no PDB entries containing danazol bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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