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DB01395 : drospirenone

Approved drug drospirenone ... 3 targets DB01395

Generic name: drospirenone
 
Brand name(s): safyral, yasmin, yaz.
Formula: C24H30O3
IUPAC Formula: (1r,2r,4r,10r,11s,14s,15s,16s,18s,19s)-10,14-
Dimethylspiro[hexacyclo[9.8.0.0^{2,4}.0^{5,10}.0^{14,19}.0^{16,18}]nonadecane-15,2'-Oxolan]-5-Ene-
5',7-Dione

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
Links  
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RxList
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P06401 (PRGR_HUMAN)  -  Progesterone receptor
UniProt id: P06401    932 a.a.  
1. 1a28 A,B     251 a.a. 251   X-ray 1.80 Å
  2. 2w8y A,B     251 a.a. 251   X-ray 1.80 Å
  3. 1zuc B,A     251 a.a. 251   X-ray 2.00 Å
  4. 1e3k A,B     251 a.a. 251   X-ray 2.80 Å
  5. 3zr7 A,B     250 a.a. 250   X-ray 1.65 Å
   more ...
There are no PDB entries containing drospirenone bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P08235 (MCR_HUMAN)  -  Mineralocorticoid receptor
UniProt id: P08235    983 a.a.  
1. 2aax A,B     261 a.a. 259   X-ray 1.75 Å
  2. 2aa6 A,B     260 a.a. 258   X-ray 1.95 Å
  3. 2ab2 A,B     259 a.a. 257   X-ray 1.85 Å
  4. 3wff A     258 a.a. 255   X-ray 2.05 Å
  5. 2aa5 A,B     255 a.a. 254   X-ray 2.20 Å
   more ...
There are no PDB entries containing drospirenone bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P10275 (ANDR_HUMAN)  -  Androgen receptor
UniProt id: P10275    918 a.a.  
1. 1xj7 A     256 a.a. 256   X-ray 2.70 Å
  2. 1t65 A     251 a.a. 251   X-ray 1.66 Å
  3. 2am9 A     250 a.a. 250   X-ray 1.64 Å
  4. 2pit A     250 a.a. 250   X-ray 1.76 Å
  5. 1t63 A     250 a.a. 250   X-ray 2.07 Å
   more ...
There are no PDB entries containing drospirenone bound to this target protein, although there are 56 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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