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DB01394 : colchicine

Approved drug colchicine ... 2 targets DB01394

Generic name: colchicine PDB Het Group: LOC
 
4 structures in PDB
Brand name(s): colcrys.
Formula: C22H25No6
IUPAC Formula: N-{3,4,5,14-Tetramethoxy-13-Oxotricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2(7),3,5,11,14-Hexaen-10-
Yl}acetamide
PDB name: N-[(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h-Benzo[d]heptalen-7-Yl]ethanamide

2
There are 2 target proteins defined in DrugBank for this drug.
 4 
There are 4 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q9H4B7 (TBB1_HUMAN)  -  Tubulin beta-1 chain
UniProt id: Q9H4B7    451 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P07437 (TBB5_HUMAN)  -  Tubulin beta chain
UniProt id: P07437    444 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain

 

Other proteins with colchicine bound in the PDB

There are 4 "non-target" proteins in the PDB containing the colchicine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: D0VWZ0 ()  -  Tubulin alpha chain OS=Ovis aries PE=1 SV=1
UniProt id: D0VWZ0    450 a.a.  
3ut5 A,C   433 a.a. 430   X-ray 2.73 Å
The PDB contains 1 entry of colchicine bound to this protein
Protein 2:   UniProt id: O60885 ()  -  Bromodomain-containing protein 4 OS=Homo sapiens GN=BRD4 PE=1 SV=2
UniProt id: O60885    1361 a.a.  
4lzr A   127 a.a. 122   X-ray 1.85 Å
The PDB contains 1 entry of colchicine bound to this protein
Protein 3:   UniProt id: P81947 ()  -  Tubulin alpha-1B chain OS=Bos taurus PE=1 SV=2
UniProt id: P81947    450 a.a.  
4o2b A,C   439 a.a. 438   X-ray 2.30 Å
The PDB contains 1 entry of colchicine bound to this protein
Protein 4:   UniProt id: Q3ZCJ7 ()  -  Tubulin alpha-1C chain OS=Bos taurus GN=TUBA1C PE=1 SV=1
UniProt id: Q3ZCJ7    448 a.a.  
3e22 A,C   427 a.a. 427   X-ray 3.80 Å
The PDB contains 1 entry of colchicine bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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