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DB01338 : pipecuronium

Approved drug pipecuronium ... 3 targets DB01338

Generic name: pipecuronium
 
Brand name(s): arduan.
Formula: C35H62N4O4
IUPAC Formula: 4-[(1s,2s,4s,5s,7s,10r,11s,13s,14r,15s)-5,14-Bis(acetyloxy)-4-(4,4-Dimethylpiperazin-4-Ium-1-Yl)-
2,15-Dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-Yl]-1,1-Dimethylpiperazin-1-Ium

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q15822 (ACHA2_HUMAN)  -  Neuronal acetylcholine receptor subunit alpha-2
UniProt id: Q15822    529 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing pipecuronium bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing pipecuronium bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

Structure selection

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