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DB01275 : hydralazine

Approved drug hydralazine ... 2 targets DB01275

Generic name: hydralazine PDB Het Group: HLZ
 
1 structure in PDB
Brand name(s): apresoline.
Formula: C8H8N4
IUPAC Formula: 1-Hydrazinylphthalazine
PDB name: 1-Hydrazinophthalazine

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q16853 (AOC3_HUMAN)  -  Membrane copper amine oxidase
UniProt id: Q16853    762 a.a.  
1. 4btw A,B     710 a.a. 709   X-ray 2.80 Å
  2. 4bty A,B     710 a.a. 709   X-ray 3.10 Å
  3. 4btx A,B     708 a.a. 707   X-ray 2.78 Å
  4. 2c10 A,B,C,D     705 a.a. 703   X-ray 2.50 Å
  5. 2y73 A,B     704 a.a. 703   X-ray 2.60 Å
   more ...
There are no PDB entries containing hydralazine bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P13674 (P4HA1_HUMAN)  -  Prolyl 4-hydroxylase subunit alpha-1
UniProt id: P13674    533 a.a.  
1. 4bta A     237 a.a. 237   X-ray 2.95 Å
  2. 4bt9 A,B     236 a.a. 236   X-ray 1.90 Å
  3. 4btb A     231 a.a. 231   X-ray 1.90 Å
  4. 2yq8 A,B     225 a.a. 225   X-ray 2.99 Å
  5. 4bt8 A,B     222 a.a. 222   X-ray 2.20 Å
   more ...
There are no PDB entries containing hydralazine bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with hydralazine bound in the PDB

There is 1 "non-target" protein in the PDB containing the hydralazine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: B2HIZ6 ()  -  Arylamine N-acetyltransferase Nat OS=Mycobacterium marinum (strain ATCC BAA-535 / M) GN=nat PE=1 SV=1
UniProt id: B2HIZ6    279 a.a.  
3ltw A   272 a.a. 272   X-ray 2.10 Å
The PDB contains 1 entry of hydralazine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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