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DB01267 : paliperidone

Approved drug paliperidone ... 17 targets DB01267

Generic name: paliperidone
 
Brand name(s): invega.
Formula: C23H27Fn4O3
IUPAC Formula: 3-{2-[4-(6-Fluoro-1,2-Benzoxazol-3-Yl)piperidin-1-Yl]ethyl}-9-Hydroxy-2-Methyl-4h,6h,7h,8h,9h-
Pyrido[1,2-A]pyrimidin-4-One

17
There are 17 target proteins defined in DrugBank for this drug.
 8 
8 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing paliperidone bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing paliperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P18825 (ADA2C_HUMAN)  -  Alpha-2C adrenergic receptor
UniProt id: P18825    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P08908 (5HT1A_HUMAN)  -  5-hydroxytryptamine 1A receptor
UniProt id: P08908    422 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing paliperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 6:   UniProt id: P08684 (CP3A4_HUMAN)  -  Cytochrome P450 3A4
UniProt id: P08684    502 a.a.  
1. 1tqn A     468 a.a. 468   X-ray 2.05 Å
  2. 4i3q A     465 a.a. 465   X-ray 2.60 Å
  3. 4ny4 A     460 a.a. 460   X-ray 2.95 Å
  4. 1w0f A     459 a.a. 459   X-ray 2.65 Å
  5. 4i4g A     459 a.a. 459   X-ray 2.72 Å
   more ...
There are no PDB entries containing paliperidone bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: P10635 (CP2D6_HUMAN)  -  Cytochrome P450 2D6
UniProt id: P10635    496 a.a.  
1. 3tbg A,B,C,D     467 a.a. 464   X-ray 2.10 Å
  2. 3tda A,B,C,D     467 a.a. 464   X-ray 2.67 Å
  3. 3qm4 A,B     465 a.a. 464   X-ray 2.85 Å
  4. 2f9q A,B,C,D     454 a.a. 451   X-ray 3.00 Å
There are no PDB entries containing paliperidone bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: P20815 (CP3A5_HUMAN)  -  Cytochrome P450 3A5
UniProt id: P20815    502 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing paliperidone bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 11:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing paliperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 12:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 14:   UniProt id: P21917 (DRD4_HUMAN)  -  D(4) dopamine receptor
UniProt id: P21917    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 15:   UniProt id: P28221 (5HT1D_HUMAN)  -  5-hydroxytryptamine 1D receptor
UniProt id: P28221    377 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 16:   UniProt id: P35462 (DRD3_HUMAN)  -  D(3) dopamine receptor
UniProt id: P35462    400 a.a.  
   more ...
There are no PDB entries containing paliperidone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 17:   UniProt id: P28335 (5HT2C_HUMAN)  -  5-hydroxytryptamine 2C receptor
UniProt id: P28335    458 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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