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DB01259 : lapatinib

Approved drug lapatinib ... 2 targets DB01259

Generic name: lapatinib PDB Het Group: FMM
 
2 structures in PDB
Brand name(s): tycerb, tykerb.
Formula: C29H26Clfn4O4S
IUPAC Formula: N-{3-Chloro-4-[(3-Fluorophenyl)methoxy]phenyl}-6-(5-{[(2-Methanesulfonylethyl)amino]methyl}furan-2-
Yl)quinazolin-4-Amine
PDB name: N-{3-Chloro-4-[(3-Fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]amino}methyl)-2-Furyl]-4-
Quinazolinamine

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Information  
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Target proteins

DrugBank drug Target 1:   UniProt id: P00533 (EGFR_HUMAN)  -  Epidermal growth factor receptor
UniProt id: P00533    1209 a.a.  
1xkk A   289 a.a. 289   X-ray 2.40 Å
The PDB contains 1 entry of lapatinib bound to this target protein and 99 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P04626 (ERBB2_HUMAN)  -  Receptor tyrosine-protein kinase erbB-2
  No Pfam domain assignments available for this protein.
1.        a.a.   Not given  
There are no PDB entries containing lapatinib bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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