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DB01235 : levodopa

Approved drug levodopa ... 5 targets DB01235

Generic name: levodopa PDB Het Group: DAH
 
4 structures in PDB
Brand name(s): bendopa, brocadopa, cidandopa, deadopa, dopaflex, dopaidan, dopal, dopal-fher, dopalina, dopar, doparkine, doparl, dopasol, dopaston, dopastral, doprin, eldopal, eldopar, eldopatec, eurodopa, helfo-dopa, insulamina, laradopa, larodopa, ledopa, levedopa, levopa, maipedopa, parda, pardopa, prodopa, syndopa, veldopa, weldopa.
Formula: C9H11No4
IUPAC Formula: (2s)-2-Amino-3-(3,4-Dihydroxyphenyl)propanoic acid
PDB name: 3,4-Dihydroxyphenylalanine

5
There are 5 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing levodopa bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P21918 (DRD5_HUMAN)  -  D(1B) dopamine receptor
UniProt id: P21918    477 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing levodopa bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P35462 (DRD3_HUMAN)  -  D(3) dopamine receptor
UniProt id: P35462    400 a.a.  
   more ...
There are no PDB entries containing levodopa bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: P21917 (DRD4_HUMAN)  -  D(4) dopamine receptor
UniProt id: P21917    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with levodopa bound in the PDB

There are 2 "non-target" proteins in the PDB containing the levodopa molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: B2ZB02 ()  -  Tyrosinase OS=Bacillus megaterium PE=1 SV=1
UniProt id: B2ZB02    296 a.a.  
4p6s A,B   286 a.a. 286   X-ray 2.20 Å
The PDB contains 1 entry of levodopa bound to this protein
Protein 2:   UniProt id: P27001 ()  -  Phenylalanine--tRNA ligase alpha subunit OS=Thermus thermophilus GN=pheS PE=1 SV=1
UniProt id: P27001    349 a.a.  
3teh A   266 a.a. 266   X-ray 2.85 Å
The PDB contains 1 entry of levodopa bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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