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DB01216 : finasteride

Approved drug finasteride ... 3 targets DB01216

Generic name: finasteride PDB Het Group: FIT
 
1 structure in PDB
Brand name(s): chibro-proscar, finastid, finpecia, propecia, proscar, prostide.
Formula: C23H36N2O2
IUPAC Formula: (1s,2r,7r,10s,11s,14s,15s)-N-Tert-Butyl-2,15-Dimethyl-5-Oxo-6-
Azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-Ene-14-Carboxamide
PDB name: (4ar,4bs,6as,7s,9as,9bs,11ar)-N-Tert-Butyl-4a,6a-Dimethyl-2-Oxo-
2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-Tetradecahydro-1h-Indeno[5,4-F]quinoline-7-Carboxamide

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P31213 (S5A2_HUMAN)  -  3-oxo-5-alpha-steroid 4-dehydrogenase 2
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P18405 (S5A1_HUMAN)  -  3-oxo-5-alpha-steroid 4-dehydrogenase 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P51857 (AK1D1_HUMAN)  -  3-oxo-5-beta-steroid 4-dehydrogenase
UniProt id: P51857    325 a.a.  
1. 3buv A,B     325 a.a. 325   X-ray 1.35 Å
  2. 3bur A,B     325 a.a. 325   X-ray 1.62 Å
  3. 3g1r A,B     325 a.a. 325   X-ray 1.70 Å
  4. 3bv7 A,B     325 a.a. 325   X-ray 1.79 Å
  5. 3cav A,B     325 a.a. 325   X-ray 1.90 Å
   more ...
There are no PDB entries containing finasteride bound to this target protein, although there are 14 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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