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DB01213 : fomepizole

Approved drug fomepizole ... 4 targets DB01213

Generic name: fomepizole PDB Het Group: 4PZ
 
Brand name(s): antizol.
Formula: C4H6N2
IUPAC Formula: 4-Methyl-1h-Pyrazole
PDB name: 4-Methyl-1h-Pyrazole

4
There are 4 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P07327 (ADH1A_HUMAN)  -  Alcohol dehydrogenase 1A
UniProt id: P07327    374 a.a.  
1. 1u3t A,B     374 a.a. 374   X-ray 2.49 Å
  2. 1hso A,B     374 a.a. 374   X-ray 2.50 Å
There are no PDB entries containing fomepizole bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P00325 (ADH1B_HUMAN)  -  Alcohol dehydrogenase 1B
UniProt id: P00325    374 a.a.  
1. 1u3u A,B     374 a.a. 374   X-ray 1.60 Å
  2. 1u3v A,B     374 a.a. 374   X-ray 1.65 Å
  3. 1deh A,B     374 a.a. 374   X-ray 2.20 Å
  4. 1hsz A,B     374 a.a. 374   X-ray 2.20 Å
  5. 1hdx A,B     374 a.a. 374   X-ray 2.50 Å
   more ...
There are no PDB entries containing fomepizole bound to this target protein, although there are 9 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P00326 (ADH1G_HUMAN)  -  Alcohol dehydrogenase 1C
UniProt id: P00326    374 a.a.  
1. 1u3w A,B     374 a.a. 372   X-ray 1.45 Å
  2. 1ht0 A,B     374 a.a. 372   X-ray 2.00 Å
  3. 1dda A,B     374 a.a. 372   Theor. model
There are no PDB entries containing fomepizole bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P04040 (CATA_HUMAN)  -  Catalase
UniProt id: P04040    526 a.a.  
1. 1qqw A,B,C,D     499 a.a. 499   X-ray 2.75 Å
  2. 1dgb A,B,C,D     498 a.a. 498   X-ray 2.20 Å
  3. 1dgf A,B,C,D     497 a.a. 497   X-ray 1.50 Å
  4. 1dgg A,B,C,D     497 a.a. 497   X-ray 1.80 Å
  5. 1dgh A,B,C,D     497 a.a. 497   X-ray 2.00 Å
There are no PDB entries containing fomepizole bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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