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DB01197 : captopril

Approved drug captopril ... 3 targets DB01197

Generic name: captopril
 
Brand name(s): acepress, acepril, alopresin, apopril, capoten, captolane, captoril, cesplon, dilabar, garranil, hipertil, hypertil, lopirin, lopril, tenosbon, tensoprel.
Formula: C9H15No3S
IUPAC Formula: (2s)-1-[(2s)-2-Methyl-3-Sulfanylpropanoyl]pyrrolidine-2-Carboxylic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
Links  
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Information  
Pharmacology
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Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P12821 (ACE_HUMAN)  -  Angiotensin-converting enzyme
UniProt id: P12821    1305 a.a.  
1. 2c6n A,B     612 a.a. 612   X-ray 3.00 Å
  2. 2c6f A,B     612 a.a. 612   X-ray 3.01 Å
  3. 4bzs A,B     612 a.a. 611   X-ray 2.10 Å
  4. 4ca6 A,B     608 a.a. 601   X-ray 1.91 Å
  5. 3nxq A,B     607 a.a. 600   X-ray 1.99 Å
   more ...
There are no PDB entries containing captopril bound to this target protein, although there are 28 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P08253 (MMP2_HUMAN)  -  72 kDa type IV collagenase
UniProt id: P08253    659 a.a.  
1. 1gxd A,B     624 a.a. 623   X-ray 3.10 Å
  2. 1ck7 A     619 a.a. 618   X-ray 2.80 Å
  3. 1eak A,B,C,D     421 a.a. 420   X-ray 2.66 Å
  4. 1rtg A     203 a.a. 203   X-ray 2.60 Å
  5. 1gen A     200 a.a. 200   X-ray 2.15 Å
   more ...
There are no PDB entries containing captopril bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P14780 (MMP9_HUMAN)  -  Matrix metalloproteinase-9
UniProt id: P14780    706 a.a.  
1. 1lkg A     707 a.a. 704   Theor. model
  2. 1l6j A     405 a.a. 404   X-ray 2.50 Å
  3. 1itv A,B     195 a.a. 193   X-ray 1.95 Å
  4. 4h3x A,B     164 a.a. 163   X-ray 1.76 Å
  5. 4h2e A,B     164 a.a. 163   X-ray 2.90 Å
   more ...
There are no PDB entries containing captopril bound to this target protein, although there are 17 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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