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DB01194 : brinzolamide

Approved drug brinzolamide ... 4 targets DB01194

Generic name: brinzolamide PDB Het Group: BZ1
 
3 structures in PDB
Brand name(s): azopt.
Formula: C12H21N3O5S3
IUPAC Formula: (4r)-4-(Ethylamino)-2-(3-Methoxypropyl)-1,1-Dioxo-2h,3h,4h-1l^{6},7,2-Thieno[3,2-
E][1l^{6},2]thiazine-6-Sulfonamide
PDB name: (+)-4-Ethylamino-3,4-Dihydro-2-(Methoxy)propyl-2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide-1,1-
Dioxide

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Target proteins

DrugBank drug Target 1:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 4m2r A   257 a.a. 257   X-ray 1.99 Å
  2. 4m2v A   257 a.a. 249   X-ray 1.72 Å
The PDB contains 2 entries of brinzolamide bound to this target protein and 487 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing brinzolamide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing brinzolamide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P35218 (CAH5A_HUMAN)  -  Carbonic anhydrase 5A, mitochondrial
UniProt id: P35218    305 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with brinzolamide bound in the PDB

There is 1 "non-target" protein in the PDB containing the brinzolamide molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q64444 ()  -  Carbonic anhydrase 4 OS=Mus musculus GN=Ca4 PE=1 SV=1
UniProt id: Q64444    304 a.a.  
3znc A   250 a.a. 249   X-ray 2.80 Å
The PDB contains 1 entry of brinzolamide bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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