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DB01189 : desflurane

Approved drug desflurane ... 7 targets DB01189

Generic name: desflurane PDB Het Group: DSF
 
1 structure in PDB
Brand name(s): suprane.
Formula: C3H2F6O
IUPAC Formula: 2-(Difluoromethoxy)-1,1,1,2-Tetrafluoroethane
PDB name: (2s)-2-(Difluoromethoxy)-1,1,1,2-Tetrafluoroethane

7
There are 7 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14867 (GBRA1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P23415 (GLRA1_HUMAN)  -  Glycine receptor subunit alpha-1
UniProt id: P23415    456 a.a.  
1. 2m6b A     150 a.a. 129   NMR  
  2. 2m6i A,B,C,D,E     150 a.a. 129   NMR  
  3. 1vry A     61 a.a. 58   NMR  
  4. 1zhd A     61 a.a. 58   NMR  
  5. 1mot A     28 a.a. 28   NMR  
There are no PDB entries containing desflurane bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P42261 (GRIA1_HUMAN)  -  Glutamate receptor 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q09470 (KCNA1_HUMAN)  -  Potassium voltage-gated channel subfamily A member 1
UniProt id: Q09470    494 a.a.  
2afl A,B,C,D     82 a.a. 82   Theor. model
There are no PDB entries containing desflurane bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: P98194 (AT2C1_HUMAN)  -  Calcium-transporting ATPase type 2C member 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P30049 (ATPD_HUMAN)  -  ATP synthase delta chain, mitochondrial
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P03886 (NU1M_HUMAN)  -  NADH-ubiquinone oxidoreductase chain 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with desflurane bound in the PDB

There is 1 "non-target" protein in the PDB containing the desflurane molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q7NDN8 ()  -  Proton-gated ion channel OS=Gloeobacter violaceus (strain PCC 7421) GN=glvI PE=1 SV=1
UniProt id: Q7NDN8    358 a.a.  
3p4w A,B,C,D,E   311 a.a. 311   X-ray 3.20 Å
The PDB contains 1 entry of desflurane bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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