spacer
spacer

Search 

DB01185 : fluoxymesterone

Approved drug fluoxymesterone ... 4 targets DB01185

Generic name: fluoxymesterone
 
Brand name(s): anadroid-f, android-f, androsterolo, fluosterone, fluotestin, flusteron, flutestos, halotestin, neo-ormonal, ora testryl, ora-testryl, oralsterone, oratestin, testoral, ultandren, ultandrene.
Formula: C20H29Fo3
IUPAC Formula: (1r,2s,10s,11s,14s,15s,17s)-1-Fluoro-14,17-Dihydroxy-2,14,15-
Trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-En-5-One

4
There are 4 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P10275 (ANDR_HUMAN)  -  Androgen receptor
UniProt id: P10275    918 a.a.  
1. 1xj7 A     256 a.a. 256   X-ray 2.70 Å
  2. 1t65 A     251 a.a. 251   X-ray 1.66 Å
  3. 2am9 A     250 a.a. 250   X-ray 1.64 Å
  4. 2pit A     250 a.a. 250   X-ray 1.76 Å
  5. 1t63 A     250 a.a. 250   X-ray 2.07 Å
   more ...
There are no PDB entries containing fluoxymesterone bound to this target protein, although there are 76 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P03372 (ESR1_HUMAN)  -  Estrogen receptor
UniProt id: P03372    594 a.a.  
1. 1qku A,B,C     250 a.a. 250   X-ray 3.20 Å
  2. 3ert A     247 a.a. 247   X-ray 1.90 Å
  3. 1g50 A,B,C     247 a.a. 247   X-ray 2.90 Å
  4. 2ouz A     246 a.a. 246   X-ray 2.00 Å
  5. 3erd A,B     246 a.a. 246   X-ray 2.03 Å
   more ...
There are no PDB entries containing fluoxymesterone bound to this target protein, although there are 102 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P16471 (PRLR_HUMAN)  -  Prolactin receptor
UniProt id: P16471    621 a.a.  
1. 3n06 B     206 a.a. 205   X-ray 2.00 Å
  2. 3mzg B     206 a.a. 205   X-ray 2.10 Å
  3. 3n0p B     206 a.a. 205   X-ray 2.10 Å
  4. 3ncb B     206 a.a. 205   X-ray 2.10 Å
  5. 3nce B     206 a.a. 204   X-ray 2.00 Å
   more ...
There are no PDB entries containing fluoxymesterone bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P04150 (GCR_HUMAN)  -  Glucocorticoid receptor
UniProt id: P04150    776 a.a.  
1. 1m2z A,D     255 a.a. 254   X-ray 2.50 Å
  2. 3bqd A     253 a.a. 252   X-ray 2.50 Å
  3. 3k22 A,B     250 a.a. 248   X-ray 2.10 Å
  4. 3e7c A,B     248 a.a. 246   X-ray 2.15 Å
  5. 4p6w A     252 a.a. 245   X-ray 1.95 Å
   more ...
There are no PDB entries containing fluoxymesterone bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer