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DB01182 : propafenone

Approved drug propafenone ... 2 targets DB01182

Generic name: propafenone
 
Brand name(s): rythmol, rythmol sr.
Formula: C21H27No3
IUPAC Formula: 1-{2-[2-Hydroxy-3-(Propylamino)propoxy]phenyl}-3-Phenylpropan-1-One

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14524 (SCN5A_HUMAN)  -  Sodium channel protein type 5 subunit alpha
UniProt id: Q14524    2015 a.a.  
1. 4dck A     153 a.a. 153   X-ray 2.20 Å
  2. 4jq0 D     142 a.a. 142   X-ray 3.84 Å
  3. 2kbi A     97 a.a. 93   NMR  
  4. 2l53 B     31 a.a. 27   NMR  
  5. 4djc B     13 a.a. 11   X-ray 1.35 Å
There are no PDB entries containing propafenone bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q12809 (KCNH2_HUMAN)  -  Potassium voltage-gated channel subfamily H member 2
UniProt id: Q12809    1158 a.a.  
1. 2l0w A     135 a.a. 134   NMR  
  2. 2l1m A     135 a.a. 134   NMR  
  3. 2l4r A     135 a.a. 134   NMR  
  4. 4hp9 A     119 a.a. 119   X-ray 2.12 Å
  5. 4hqa A     110 a.a. 110   X-ray 1.96 Å
   more ...
There are no PDB entries containing propafenone bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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