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DB01177 : idarubicin

Approved drug idarubicin ... 2 targets DB01177

Generic name: idarubicin PDB Het Group: DM5
 
5 structures in PDB
Brand name(s): idamycin, idamycin pfs, idarubicin aglycone, idarubicin hcl pfs.
Formula: C26H27No9
IUPAC Formula: (7s,9s)-9-Acetyl-7-{[(2r,4s,5s,6s)-4-Amino-5-Hydroxy-6-Methyloxan-2-Yl]oxy}-6,9,11-Trihydroxy-
5,7,8,9,10,12-Hexahydrotetracene-5,12-Dione
PDB name: Idarubicin

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P11388 (TOP2A_HUMAN)  -  DNA topoisomerase 2-alpha
UniProt id: P11388    1530 a.a.  
1. 1lwz A     779 a.a. 771   Theor. model
  2. 4fm9 A     727 a.a. 727   X-ray 2.90 Å
  3. 1zxm A,B     373 a.a. 373   X-ray 1.87 Å
  4. 1zxn A,B,C,D     366 a.a. 366   X-ray 2.51 Å
There are no PDB entries containing idarubicin bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with idarubicin bound in the PDB

There is 1 "non-target" protein in the PDB containing the idarubicin molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q9AMP1 ()  -  Chitinase A OS=Vibrio harveyi GN=chiA PE=1 SV=1
UniProt id: Q9AMP1    849 a.a.  
3arq A   575 a.a. 575   X-ray 1.50 Å
The PDB contains 1 entry of idarubicin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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