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DB01174 : phenobarbital

Approved drug phenobarbital ... 10 targets DB01174

Generic name: phenobarbital
 
Brand name(s): adonal, aephenal, agrypnal, amylofene, aphenylbarbit, aphenyletten, barbenyl, barbinal, barbiphen, barbiphenyl, barbipil, barbita, barbivis, barbonal, barbophen, bardorm, bartol, bialminal, blu-phen, cabronal, calmetten, calminal, cardenal, chinoin, codibarbita, coronaletta, cratecil, damoral, dezibarbitur, dormina, dormiral, dormital, doscalun, duneryl, ensobarb, ensodorm, epanal, epidorm, epilol, episedal, epsylone, eskabarb, etilfen, euneryl, fenbital, fenemal, fenosed, fenylettae, gardenal, gardepanyl, glysoletten, haplopan, haplos, helional, hennoletten, henotal, hypnaletten, hypnette, hypno-tablinetten, hypnogen, hypnolone, hypnoltol, hysteps, lefebar, leonal, lephebar, lepinal, lepinaletten, linasen, liquital, lixophen, lubergal, lubrokal, lumen, lumesettes, lumesyn, luminal, lumofridetten, luphenil, luramin, molinal, neurobarb, nirvonal, noptil, nova-pheno, nunol, parkotal, pharmetten, phen-bar, phenaemal, phenemal, phenemalum, phenobal, phenobarbyl, phenoluric, phenolurio, phenomet, phenonyl, phenoturic, phenyletten, phenyral, phob, polcominal, promptonal, seda-tablinen, sedabar, sedicat, sedizorin, sedlyn, sedofen, sedonal, sedonettes, sevenal, sinoratox, solfoton, solfoton talpheno, solu-barb, sombutol, somnolens, somnoletten, somnosan, somonal, spasepilin, starifen, starilettae, stental, stental extentabs, talpheno, teolaxin, teoloxin, thenobarbital, theoloxin, triabarb, tridezibarbitur, triphenatol, versomnal, zadoletten, zadonal.
Formula: C12H12N2O3
IUPAC Formula: 5-Ethyl-5-Phenyl-1,3-Diazinane-2,4,6-Trione

10
There are 10 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q13002 (GRIK2_HUMAN)  -  Glutamate receptor, ionotropic kainate 2
UniProt id: Q13002    907 a.a.  
3qxm A,B     250 a.a. 250   X-ray 1.65 Å
There are no PDB entries containing phenobarbital bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P14867 (GBRA1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-1
UniProt id: P14867    456 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P47869 (GBRA2_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-2
UniProt id: P47869    451 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P34903 (GBRA3_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-3
UniProt id: P34903    492 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P48169 (GBRA4_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-4
UniProt id: P48169    554 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P31644 (GBRA5_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-5
UniProt id: P31644    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: Q16445 (GBRA6_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-6
UniProt id: Q16445    453 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P43681 (ACHA4_HUMAN)  -  Neuronal acetylcholine receptor subunit alpha-4
UniProt id: P43681    626 a.a.  
1. 2gvt A,C     204 a.a. 204   Theor. model
  2. 2lly A     134 a.a. 98   NMR  
There are no PDB entries containing phenobarbital bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 9:   UniProt id: P36544 (ACHA7_HUMAN)  -  Neuronal acetylcholine receptor subunit alpha-7
UniProt id: P36544    501 a.a.  
2maw A     134 a.a. 93   NMR  
There are no PDB entries containing phenobarbital bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 10:   UniProt id: P42262 (GRIA2_HUMAN)  -  Glutamate receptor 2
UniProt id: P42262    882 a.a.  
1. 2wjw A     368 a.a. 368   X-ray 1.80 Å
  2. 2wjx A,B,C     363 a.a. 363   X-ray 4.10 Å
  3. 3r7x A,B     259 a.a. 258   X-ray 2.10 Å
  4. 3rnn A,B,C     259 a.a. 257   X-ray 1.75 Å
  5. 3rn8 A,B,C     258 a.a. 256   X-ray 1.70 Å
   more ...
There are no PDB entries containing phenobarbital bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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