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DB01162 : terazosin

Approved drug terazosin ... 6 targets DB01162

Generic name: terazosin
 
Brand name(s): blavin, flumarc, fosfomic, heitrin, hytracin, hytrin, hytrinex, itrin, urodie, vasomet, vicard.
Formula: C19H25N5O4
IUPAC Formula: 6,7-Dimethoxy-2-{4-[(Oxolan-2-Yl)carbonyl]piperazin-1-Yl}quinazolin-4-Amine

6
There are 6 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P25100 (ADA1D_HUMAN)  -  Alpha-1D adrenergic receptor
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q12809 (KCNH2_HUMAN)  -  Potassium voltage-gated channel subfamily H member 2
UniProt id: Q12809    1158 a.a.  
1. 2l0w A     135 a.a. 134   NMR  
  2. 2l1m A     135 a.a. 134   NMR  
  3. 2l4r A     135 a.a. 134   NMR  
  4. 4hp9 A     119 a.a. 119   X-ray 2.12 Å
  5. 4hqa A     110 a.a. 110   X-ray 1.96 Å
   more ...
There are no PDB entries containing terazosin bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: Q9H252 (KCNH6_HUMAN)  -  Potassium voltage-gated channel subfamily H member 6
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: Q9NS40 (KCNH7_HUMAN)  -  Potassium voltage-gated channel subfamily H member 7
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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