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DB01159 : halothane

Approved drug halothane ... 17 targets DB01159

Generic name: halothane
 
Brand name(s): anestan, chalothane, fluktan, fluothane, halan, halotan, halothane, halsan, narcotan, narcotane, narkotan, phthorothanum, rhodialothan.
Formula: C2Hbrclf3
IUPAC Formula: 2-Bromo-2-Chloro-1,1,1-Trifluoroethane

17
There are 17 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P48549 (KCNJ3_HUMAN)  -  G protein-activated inward rectifier potassium channel 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P03886 (NU1M_HUMAN)  -  NADH-ubiquinone oxidoreductase chain 1
UniProt id: P03886    318 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: O15554 (KCNN4_HUMAN)  -  Intermediate conductance calcium-activated potassium channel protein 4
UniProt id: O15554    427 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P30049 (ATPD_HUMAN)  -  ATP synthase delta chain, mitochondrial
UniProt id: P30049    168 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P98194 (AT2C1_HUMAN)  -  Calcium-transporting ATPase type 2C member 1
UniProt id: P98194    919 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P14867 (GBRA1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-1
UniProt id: P14867    456 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P59768 (GBG2_HUMAN)  -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit
UniProt id: P59768    70 a.a.  
1. 4kfm G     60 a.a. 60   X-ray 3.45 Å
  2. 2qns B     53 a.a. 53   X-ray 3.00 Å
  3. 3kj5 B     53 a.a. 53   X-ray 3.00 Å
There are no PDB entries containing halothane bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: Q6W5P4 (NPSR1_HUMAN)  -  Neuropeptide S receptor
UniProt id: Q6W5P4    371 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: O14649 (KCNK3_HUMAN)  -  Potassium channel subfamily K member 3
UniProt id: O14649    394 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: Q9NPC2 (KCNK9_HUMAN)  -  Potassium channel subfamily K member 9
UniProt id: Q9NPC2    374 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: Q12791 (KCMA1_HUMAN)  -  Calcium-activated potassium channel subunit alpha 1
UniProt id: Q12791    1235 a.a.  
1. 3naf A     632 a.a. 616   X-ray 3.10 Å
  2. 3mt5 A     593 a.a. 593   X-ray 3.00 Å
  3. 2k44 A     28 a.a. 28   NMR  
There are no PDB entries containing halothane bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 12:   UniProt id: Q8TCU5 (NMD3A_HUMAN)  -  Glutamate [NMDA] receptor subunit 3A
UniProt id: Q8TCU5    1115 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: O60391 (NMD3B_HUMAN)  -  Glutamate [NMDA] receptor subunit 3B
UniProt id: O60391    1043 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 14:   UniProt id: Q12879 (NMDE1_HUMAN)  -  Glutamate [NMDA] receptor subunit epsilon-1
UniProt id: Q12879    1464 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 15:   UniProt id: P23415 (GLRA1_HUMAN)  -  Glycine receptor subunit alpha-1
UniProt id: P23415    456 a.a.  
1. 2m6b A     150 a.a. 129   NMR  
  2. 2m6i A,B,C,D,E     150 a.a. 129   NMR  
  3. 1vry A     61 a.a. 58   NMR  
  4. 1zhd A     61 a.a. 58   NMR  
  5. 1mot A     28 a.a. 28   NMR  
There are no PDB entries containing halothane bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 16:   UniProt id: P08100 (OPSD_HUMAN)  -  Rhodopsin
UniProt id: P08100    348 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 17:   UniProt id: P48051 (KCNJ6_HUMAN)  -  G protein-activated inward rectifier potassium channel 2
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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